Results 101 to 110 of about 52,301 (321)
An Integrated Model of Minor Intron Emergence and Conservation
Frontiers in Genetics, 2019 Minor introns constitute <0.5% of the introns in the human genome and have remained an enigma since their discovery. These introns are removed by a distinct splicing complex, the minor spliceosome. Both are ancient, tracing back to the last eukaryotic
Marybeth Baumgartner +4 more
doaj +1 more source
Multicellular Sprouting In Vitro [PDF]
Biophysical Journal, 2008 Cell motility and its guidance through cell-cell contacts is instrumental in vasculogenesis and in other developmental or pathological processes as well. During vasculogenesis, multicellular sprouts invade rapidly into avascular areas, eventually creating a polygonal pattern.
Szabo, Andras +3 more
openaire +2 more sources
How the evolution of multicellularity set the stage for cancer
British Journal of Cancer, 2018 Neoplastic growth and many of the hallmark properties of cancer are driven by the disruption of molecular networks established during the emergence of multicellularity.
A. Trigos +3 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.This study introduces a novel multi‐scale scaffold design using L‐fractals arranged in Archimedean tessellations for tissue regeneration. Despite similar porosity, tiles display vastly different tensile responses (1–100 MPa) and deformation modes. In vitro experiments with hMSCs show geometry‐dependent growth and activity. Over 55 000 tile combinations
Maria Kalogeropoulou +4 more
wiley +1 more source
Advanced Functional Materials, EarlyView.A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker +16 more
wiley +1 more source
De novo origins of multicellularity in response to predation
Scientific Reports, 2018 The transition from unicellular to multicellular life was one of a few major events in the history of life that created new opportunities for more complex biological systems to evolve.
M. Herron +8 more
semanticscholar +1 more source
Multifunctional Microstructured Surfaces by Microcontact Printing of Reactive Microgels
Advanced Functional Materials, EarlyView.Reactive poly(N‐vinylcaprolactam‐co‐glycidyl methacrylate) microgels are used as functional inks to create surface‐grafted arrays on glass via microcontact printing. The patterns (10–50 µm widths and spacings) enable stable binding and post‐functionalization with dyes and peptides.
Inga Litzen +4 more
wiley +1 more source
Mètode Science Studies Journal: Annual Review, 2020 When asked about cancer, most would first think of it as a devastating disease. Some might add that lifestyle (e.g., smoking) or environmental pollution has something to do with it, but also that it tends to occur in old people.
E. Yagmur Erten, Hanna Kokko
doaj +1 more source
Stabilizing multicellularity through ratcheting [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2016 The evolutionary transition to multicellularity probably began with the formation of simple undifferentiated cellular groups. Such groups evolve readily in diverse lineages of extant unicellular taxa, suggesting that there are few genetic barriers to this first key step.
Libby, Eric +3 more
openaire +2 more sources
Generating Cell Surface Nucleated Hydrogels with an Artificial Membrane‐Binding Transglutaminase
Advanced Functional Materials, EarlyView.Cell‐based therapies require advanced strategies to enhance cell delivery and bioactivity. Cell membrane engineering offers an avenue to impart new functions to delivered cells to boost their viability and function. Here, an artificial membrane‐binding transglutaminase is generated and biophysically characterized.
Rosalia Cuahtecontzi Delint +6 more
wiley +1 more source