Results 1 to 10 of about 21,386 (303)

EBV+ and Kaposi’s Sarcoma Herpesvirus-Associated Multicentric Castleman Disease in a Patient With HIV Infection: A Case Report [PDF]

Case Reports in Infectious Diseases
Multicentric Castleman disease is a rare proliferative disease of lymphoid tissue. It has rarely been reported in Asian countries, particularly in HIV-positive patients.
Mai-Yin Huang, Zhe Li, Wei Zhang, Hai-Yun Chen, Jun Liu, Chong-Xi Li   +5 more
doaj   +3 more sources

Diagnostic challenges of the idiopathic plasmacytic lymphadenopathy (IPL) subtype of idiopathic multicentric Castleman disease (iMCD): Factors to differentiate from IgG4-related disease. [PDF]

J Clin Pathol
Aims and methods Idiopathic multicentric Castleman disease (iMCD) is currently considered to be classified into three clinical subtypes, including idiopathic plasmacytic lymphadenopathy (IPL), thrombocytopaenia, anasarca, fever, reticulin fibrosis/renal ...
Nishikori A, Nishimura MF, Fajgenbaum DC, Nishimura Y, Maehama K, Haratake T, Tabata T, Kawano M, Nakamura N, Momose S, Sumiyoshi R, Koga T, Yamamoto H, van Rhee F, Kawakami A, Sato Y.   +15 more
europepmc   +4 more sources

Novel insights and therapeutic approaches in idiopathic multicentric Castleman disease [PDF]

Blood, 2018
Castleman disease (CD) describes a heterogeneous group of hematologic disorders that share characteristic lymph node histopathology. Patients of all ages present with either a solitary enlarged lymph node (unicentric CD) or multicentric lymphadenopathy ...
David C Fajgenbaum
exaly   +3 more sources

CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease

Nature Communications, 2022
Idiopathic multicentric Castleman disease (iMCD) is a life-threatening inflammatory disease requiring immediate intervention, for which the recommended first-line therapy is the Interleukin-6 pathway inhibitor siltuximab.
Sheila K Pierson, Melanie D Mumau
exaly   +3 more sources

Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease. [PDF]

Blood Advances, 2021
Idiopathic multicentric Castleman disease (iMCD) is a poorly-understood hematologic disorder involving cytokine-induced polyclonal lymphoproliferation, systemic inflammation, and potentially-fatal multi-organ failure.
S. Pierson, Sushila A. Shenoy, A. Oromendia, A. Gorzewski, R. Pai, C. Nabel, J. Ruth, Sophia A T Parente, Daniel J. Arenas, M. Guilfoyle, M. P. Reddy, M. Weinblatt, N. Shadick, M. Bower, A. Dalla Pria, Y. Masaki, Laura Katz, J. Mezey, Philip Beineke, David S. Lee, C. Tendler, T. Kambayashi, A. Fosså, F. van Rhee, D. Fajgenbaum   +24 more
semanticscholar   +2 more sources

Bone marrow findings of idiopathic Multicentric Castleman disease: A histopathologic analysis and systematic literature review

Hematological Oncology, 2022
Idiopathic multicentric Castleman disease (iMCD) is a polyclonal lymphoproliferative disorder characterized by constitutional symptoms, generalized lymphadenopathy, cytopenias, and multi‐organ dysfunction due to excessive cytokines, notably Interleukin‐6.
E. Belyaeva, Ayelet Rubenstein, S. Pierson, D. Dalldorf, D. Frank, M. Lim, D. Fajgenbaum   +6 more
semanticscholar   +3 more sources

HHV-8-Associated Multicentric Castleman Disease, a Diagnostic Challenge in a Patient With Acquired Immunodeficiency Syndrome and Fever

Journal of Investigative Medicine High Impact Case Reports, 2022
Patients with acquired immunodeficiency syndrome (AIDS) are at an increased susceptibility to pathogens and associated malignancies which can present with a unique constellation of symptoms.
Robert Dunn MS4, Roopam Jariwal MD, Frederick Venter MD, Shikha Mishra MD, Janpreet Bhandohal MD, Everado Cobos MD, Arash Heidari MD   +6 more
doaj   +2 more sources

The lymph node transcriptome of unicentric and idiopathic multicentric Castleman disease

Haematologica, 2022
Castleman disease is a polyclonal lymphoproliferative disorder characterized by unicentric or multicentric lymphadenopathy with characteristic histomorphological features, in addition to variable inflammatory symptomatology. The molecular mechanisms and
Pedro Horna, Rebecca L. King, Dragan Jevremovic, David C. Fajgenbaum, Angela Dispenzieri   +4 more
doaj   +2 more sources

A Review of Genetic Abnormalities in Unicentric and Multicentric Castleman Disease

Biology, 2021
Castleman disease (CD) is a rare lymphoproliferative disorder known to represent at least four distinct clinicopathologic subtypes. Large advancements in our clinical and histopathologic description of these diverse diseases have been made, resulting in ...
Alexandra Butzmann, Jyoti Kumar, Kaushik Sridhar, Sumanth Gollapudi, Robert S. Ohgami   +4 more
doaj   +2 more sources

Idiopathic multicentric Castleman disease developing after a diagnosis of sarcoidosis: A case report and literature review [PDF]

Respiratory Medicine Case Reports
A 72-year-old woman presented with an abnormal shadow on chest radiograph. She was histologically diagnosed with sarcoidosis 20 years previously, and prednisolone was initiated 8 years previously.
Takumi Muramatsu, Masato Kono, Masaki Ishige, Takahiko Saito, Misato Higasa, Fumiya Nihashi, Yuya Aono, Mineo Katsumata, Hideki Miwa, Yoshihiro Miki, Taro Misaki, Yoshiro Otsuki, Dai Hashimoto, Noriyuki Enomoto, Takafumi Suda, Hidenori Nakamura   +15 more
doaj   +2 more sources