Results 261 to 270 of about 21,386 (303)

Idiopathic multicentric Castleman disease (iMCD)‐idiopathic plasmacytic lymphadenopathy: A distinct subtype of iMCD‐not otherwise specified with different clinical features and better survival

British Journal of Haematology
Idiopathic multicentric Castleman disease (iMCD) is subclassified into iMCD‐thrombocytopenia, anasarca, reticulin fibrosis, renal dysfunction, organomegaly (TAFRO) and iMCD‐not otherwise specified (NOS) according to the Castleman Disease Collaborative ...
Yu-han Gao, Yan-ting Liu, Miao-yan Zhang, Si-yuan Li, D. Fajgenbaum, Lu Zhang, Jian Li   +6 more
semanticscholar   +1 more source

Multicentric Castleman Disease

2013
Multicentric Castleman disease is a systemic disorder of lymph nodes characterized by inflammatory symptoms including fever, night sweats, cachexia, malaise, and lymphadenopathy together with laboratory abnormalities including anemia and hypoalbuminemia. These symptoms may be life-threatening. The diagnosis is based on specific pathological findings in
Mark N. Polizzotto, Thomas S. Uldrick, Robert Yarchoan   +2 more
openaire   +2 more sources

Unicentric and multicentric Castleman's disease

The British Journal of Radiology, 2007
Castleman's disease (CD) appears at ubiquitous lymph nodes. To date, detection of the lesion focus for CD has mainly been carried out by physical examination and radiological findings, such as X-ray analysis, CT and MRI. 18F-FDG PET visualizes the active focus of glucose metabolism and the clinical value has been investigated for many different tumours.
K, Enomoto, I, Nakamichi, K, Hamada, A, Inoue, I, Higuchi, M, Sekimoto, M, Mizuki, Y, Hoshida, T, Kubo, K, Aozasa, J, Hatazawa   +10 more
openaire   +2 more sources

Siltuximab for multicentric Castleman disease

Expert Review of Hematology, 2014
Dysregulated secretion of IL-6 plays a pivotal role in the pathogenesis of Castleman disease (CD), a rare lymphoproliferative disorder. In contrast to unicentric CD for which surgery is considered the treatment of choice, there is no standard therapeutic approach for multicentric CD (MCD). Siltuximab (trade name: Sylvant, formerly known as CNTO 328) is
Yi-Chang, Liu, Katie, Stone, Frits, van Rhee   +2 more
openaire   +2 more sources

Multicentric Castleman Disease Presenting with Fever

The Journal of Pediatrics, 2014
Multicentric Castleman disease (MCD) is a rare lymphoproliferative disorder that usually manifests with nonspecific symptoms, including fever and lymphadenopathy. Treatment of pediatric MCD varies greatly. A 21-month-old child was diagnosed with MCD after presenting with fever.
Christiana, Smith, Cathy, Lee-Miller, Megan K, Dishop, Carrye, Cost, Michael, Wang, Edwin J, Asturias   +5 more
openaire   +2 more sources

Multicentric Castleman's disease in HIV infection

International Journal of STD & AIDS, 2006
Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder. The precise incidence is unknown, although it is more common in HIV-positive than HIV-negative individuals. The pathological features of MCD strongly suggest a chronic antigen stimulation response, and human herpes virus 8 (HHV8) has been found to be universal in cases of ...
L S, Collins, A, Fowler, C Y W, Tong, A, de Ruiter   +3 more
openaire   +2 more sources

In silico insights on IL-6: A Potential target for Multicentric Castleman Disease.

Current Computer - Aided Drug Design, 2020
Multicentric Castleman Disease (MCD) is a confrontational lymphoproliferative disorder described by symptoms such as lymph node proliferation, unwarranted secretion of inflammatory cytokines, hyperactive immune system, and in severe cases, multiple ...
Abhishek Aher, Trishang Udhwani, Ravina Khandelwal, Akanksha Limaye, T. Hussain, Anuraj Nayarisseri, S. Singh   +6 more
semanticscholar   +1 more source

Clinical dissection of multicentric Castleman disease

Leukemia & Lymphoma, 2011
This study investigated the prognostic factors of Castleman disease (CD) and focused specifically on multicentric CD (MCD). Seventy patients with CD were studied. Forty-three patients (61.5%) had unicentric CD (UCD) and 27 patients (38.5%) had MCD.
Dong-Yeop, Shin, Yoon Kyung, Jeon, Yong-Sang, Hong, Tae Min, Kim, Se-Hoon, Lee, Dong-Wan, Kim, Inho, Kim, Sung-Soo, Yoon, Dae Seog, Heo, Seonyang, Park, Byoung Kook, Kim   +10 more
openaire   +2 more sources

Fifty years of multicentric Castleman's disease

Acta Oncologica, 2004
Benjamin Castleman first described multicentric Castleman's disease (MCD) in a series of cases in 1954. Interest in MCD has grown in recent years following an association with human immunodeficiency virus (HIV) infection. Castleman's disease is separated into localized disease and MCD.
Ashita, Waterston, Mark, Bower
openaire   +2 more sources

Multicentric Castleman’s disease in two cases

The Indian Journal of Pediatrics, 2007
Castleman's disease is an atypical lymphoproliferative disorder having two types of presentation--the localized and the multicentric form. The localized form presents as a slowly growing mass with a relatively benign course. Multicentric Castleman's disease has a more aggressive clinical course with diffuse lymph node enlargement and systemic illness ...
Rajni, Sharma, Rachna, Seth, V, Thavaraj, A, Bagga, S K, Kabra, A K, Karak, S, Atri   +6 more
openaire   +2 more sources