Results 31 to 40 of about 168,010 (302)

Multidisciplinary Engineering Systems 2nd and 3rd Year College-Wide Courses [PDF]

, 2010
Undergraduate engineering education today is ineffective in preparing students for multidisciplinary system integration and optimization - exactly what is needed by companies to become innovative and gain a competitive advantage in this global economy ...
Craig, Kevin, Nagurka, Mark L.
core   +2 more sources

Analytical Sensitivity Analysis of Dynamic Problems with Direct Differentiation of Generalized-α Time Integration

Machines
In this paper, the direct differentiation of generalized-α time integration is derived, equations are introduced and results are shown. Although generalized-α time integration has found usage, the derivation and the resulting equations for the analytical
Erich Wehrle, Veit Gufler
doaj   +1 more source

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

An improved particle swarm optimization algorithm for dynamic analysis of chain drive based on multidisciplinary design optimization

Advances in Mechanical Engineering, 2019
Chain drive is one of the most commonly used mechanical devices in the main equipment transmission system. In the past decade, scholars focused on basic performance research, but ignore its best performance.
Mengjiang Chai, Yongliang Yuan, Wenjuan Zhao   +2 more
doaj   +1 more source

Decoupled UMDO formulation for interdisciplinary coupling satisfaction under uncertainty [PDF]

, 2014
International audienceAt early design phases, taking into account uncertainty for the optimization of a multidisciplinary system is essential to establish the optimal system characteristics and performances.
Balesdent, Mathieu, Brevault, Loïc, Bérend, Nicolas, Le Riche, Rodolphe   +3 more
core   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

A multidisciplinary coupling relationship coordination algorithm using the hierarchical control methods of complex systems and its application in multidisciplinary design optimization

Advances in Mechanical Engineering, 2016
Because of the increasing complexity in engineering systems, multidisciplinary design optimization has attracted increasing attention. High computational expense and organizational complexity are two main challenges of multidisciplinary design ...
Rong Yuan, Haiqing Li
doaj   +1 more source

Streamlining Cross-Organizational Aircraft Development: Results from the AGILE Project [PDF]

, 2019
The research and innovation AGILE project developed the next generation of aircraft Multidisciplinary Design and Optimization processes, which target significant reductions in aircraft development costs and time to market, leading to more cost-effective ...
Aigner, Benedikt, Anisimov, Kirill, Bartoli, Nathalie, Cerino, Giovanni, Charbonnier, Dominique, Ciampa, Pier Davide, Della Vecchia, Pierluigi, Fioriti, Marco, Jungo, Aidan, La Rocca, Gianfranco, Lefebvre, Thierry, Maierl, Reinhold, Mirzoyan, Artur, Prakasha, Prajwal S., Rajpal, Darwin, Stingo, Luca, Timmermans, Huub, Torrigiani, Francesco, van Gent, Imco, Voskuijl, Mark, Walther, Jan-Niclas   +20 more
core   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Multidisciplinary Reliability Design Optimization Modeling Based on SysML

Applied Sciences
Model-Based Systems Engineering (MBSE) supports the system-level design of complex products effectively. Currently, system design and optimization for complex products are two distinct processes that must be executed using different software or platforms,
Qiang Zhang, Jihong Liu, Xu Chen
doaj   +1 more source