Results 101 to 110 of about 4,149,746 (288)

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Design Optimization of a Pseudo-Rigid-Compliant Mechanism for Large, Continuous, and Smooth Morphing of Airfoil Camber

Aerospace
This work introduces a novel variable camber mechanism that combines the high-load capacity, structural stability, and mechanical efficiency of rigid-body mechanisms with the adaptability, lightweight design, and continuous and smooth motion of compliant
Victor Alulema, Victor Hidalgo, Edgar Cando, Esteban Valencia   +3 more
doaj   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Development of a Low-Speed Wind Turbine for Brazilian Onshore Areas: A Preliminary and Conceptual Design

IEEE Open Access Journal of Power and Energy
This article presents a comprehensive design study of a low-speed wind turbine optimized for regions with weak wind resources, with a particular focus on Brazil’s extensive territories.
James Rojas Waterhouse, Cristhian R. Morante Villarreal, Guilherme Beppu de Souza, Fernando Vilas Boas Ribeiro, Carlos Henrique Gasparetti, Kauan Pires Quevedo, Josiel Goncalves Dos Santos, George Camargo Dos Santos, Marlos Jose Ribeiro Guimaraes   +8 more
doaj   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Design and Optimization of Lightweight Electromagnetic Valves for High-Altitude Latex Balloons

Machines
To address the altitude control requirements of high-altitude latex balloons, this paper proposes a novel lightweight electromagnetically actuated valve design.
Xiaoran Li, Donghui Zhang, Qiguang Yang, Zihao Wang, Chen Chen   +4 more
doaj   +1 more source

Translational Barriers and AI‐Driven Challenges of Microfluidics‐Enabled Wearables and Implantable Systems in Personalized Medicine

Advanced Science, EarlyView.
An integrative review of microfluidics‐enabled wearables and implantable systems reveals a single‐track translation pipeline, bridging functional biomaterials with clinical utility. Dynamic feedback loops driven by artificial intelligence advance diagnostics toward personalized closed‐loop theranostics.
Ke Huang, Ching Yin Fong, Xin Huang, Bee Luan Khoo   +3 more
wiley   +1 more source

Why Methods for Optimization Problems with Time-Consuming Function Evaluations and Integer Variables Should Use Global Approximation Models [PDF]

This paper advocates the use of methods based on global approximation models for optimization problems with time-consuming function evaluations and integer variables.We show that methods based on local approximations may lead to the integer rounding of ...
Brekelmans, R.C.M., Gerichhausen, M., Hamers, H.J.M., Hertog, D. den, Driessen, L.   +4 more
core  

Efficient polar optimization of transport aircraft in transonic RANS flow using adjoint gradient based approach [PDF]

, 2012
A major design requirement for transport aircraft is efficient cruise flight in the transonic region. From the aerodynamic viewpoint, this is achieved by favorable lift-to-drag ratio of the aircraft, both at the main design point and at off-design ...
Brezillon, Joel, Ilic, Caslav, Widhalm, Markus   +2 more
core  

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source