Results 161 to 170 of about 150,968 (195)

DVL, a Lectin from <i>Dioclea violacea</i> Seeds, Disturbs the Proteomic Profile of <i>Candida krusei,</i> Leading to Cell Death. [PDF]

Antibiotics (Basel)
Silva RRS, Carvalho RJP, Santos MHC, Santos ALE, Carneiro RF, Nagano CS, Souza PFN, Teixeira CS.   +7 more
europepmc   +1 more source

Repurposing loratadine to reverse colistin resistance in <i>Klebsiella pneumoniae</i> through targeting lipid A modification. [PDF]

Emerg Microbes Infect
Wu X, Ge Z, Zhan H, Zheng M, Feng Y, Zhai Y, Yuan L, Liu J, Pan Y, Hu G, Ma X, He D.   +11 more
europepmc   +1 more source

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Multidrug resistance-associated proteins in glaucoma surgery

Graefe's Archive for Clinical and Experimental Ophthalmology, 2000
Multidrug resistance (MDR) describes the phenomenon of cross-resistance between different cytostatic agents which are structurally and functionally dissimilar. Two recently discovered proteins, lung resistance protein (LRP) and the multidrug resistance-related protein (MRP) have been implicated in the development of MDR.
J, Esser, P, Esser, H, Mietz, A, Hueber, N, Kociok, U, Schraermeyer, G K, Krieglstein   +6 more
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Plasmodium falciparum expresses a multidrug resistance-associated protein

Biochemical and Biophysical Research Communications, 2004
Plasmodium falciparum proteins that efflux toxic metabolic products such as oxidised glutathione (GSSG) are possible targets for anti-malarial drug development. Proteins capable of transporting GSSG and glutathione conjugates include the multidrug resistance-associated transporters (MRPs). A gene, PFA0590w, encoding a MRP homologue, has been identified
Antonios, Klokouzas, Teresa, Tiffert, Donelly, van Schalkwyk, Chung-Pu, Wu, Hendrik W, van Veen, Margery A, Barrand, Stephen B, Hladky   +6 more
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Multidrug resistance-associated protein (MRP) in haematological malignancies

Leukemia & Lymphoma, 1996
The presence of multidrug resistant cells, either acquired or de novo, severely limits treatment outcome in haematological malignancies. Although expression of the Mr 170,000 P-glycoprotein drug pump is likely to play a role in multidrug resistance (MDR) in haematological malignancies, it is now evident that other MDR mechanisms may be operational as ...
K, Nooter, H, Burger, G, Stoter
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Pharmacogenomics of Human Multidrug Resistance Associated Proteins

Current Pharmacogenomics and Personalized Medicine, 2008
Inter-individual variations in response to pharmacotherapy such as adverse effects, treatment resistance and toxicities affect all patient populations. Multidrug resistance associated proteins (MRPs) work as efflux pumps for many xenobiotics and endogenous substances and hence, can affect the drug concentration at the target site which governs ...
Shu-Feng Zhou, Jana Fulcher
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Multidrug resistance‐associated proteins and implications in drug development

Clinical and Experimental Pharmacology and Physiology, 2009
Summary1. The multidrug resistance‐associated proteins (MRPs) belong to the ATP‐binding cassette superfamily (ABCC family) of transporters that are expressed differentially in the liver, kidney, intestine and blood–brain barrier. There are nine human MRPs that transport a structurally diverse array of endo‐ and xenobiotics as well as their conjugates.2.
Ya-He, Liu, Yuan-Ming, Di, Zhi-Wei, Zhou, Sui-Lin, Mo, Shu-Feng, Zhou   +4 more
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The Multidrug Resistance-Associated Protein — MRP

1995
The development of the multidrug resistant (MDR) phenotype in cancer cells is the major obstacle to successful chemotherapy. Elucidation of the mechanisms that determine inherent resistance or chemotherapy-induced resistance of human tumors to many of the anticancer agents currently used in the clinic, is of great interest to researchers and great ...
Dominic Fan, Diane R. Bielenberg, Yun-Fang Wang, Robert Radinsky, Pedro J. Beltran   +4 more
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