Results 171 to 180 of about 150,968 (195)

Glutathione Peptidomimetic Drug Modulator of Multidrug Resistance-Associated Protein

The Journal of Pharmacology and Experimental Therapeutics, 1999
The peptidomimetic drug gamma-glutamyl-S-(benzyl)cysteinyl-R-(-)-phenyl glycine diethyl ester (TER199) is an analog of glutathione designed to be an isozyme-specific inhibitor of GSTP1-1 protein1-1. This compound (and the de-esterified moiety) is shown to be an effective inhibitor of multidrug resistance-associated protein1 (MRP1)-mediated drug ...
M L, O'Brien, B, Vulevic, S, Freer, J, Boyd, H, Shen, K D, Tew   +5 more
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Human Multidrug Resistance Associated Protein 4 Confers Resistance to Camptothecins

Pharmaceutical Research, 2005
The multidrug resistance associated protein (MRP) 4 is a member of the adenosine triphosphate (ATP)-binding cassette transporter family. Camptothecins (CPTs) have shown substantial anticancer activity against a broad spectrum of tumors by inhibiting DNA topoisomerase I, but tumor resistance is one of the major reasons for therapeutic failure.
Tian, Quan, Zhang, Jing, Tan, Theresa May Chin, Chan, Eli, Duan, Wei, Chan, Sui Yung, Boelsterli, Urs Alex, Ho, Paul Chi-Lui, Yang, Hongyuan, Bian, Jin-Song, Huang, Min, Zhu, Yi-Zhun, Xiong, Weiping, Li, Xiaotian, Zhou, Shufeng   +14 more
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The role of multidrug resistance-associated protein (MRP) expression in multidrug resistance

Anti-Cancer Drugs, 1997
Multidrug resistance (MDR) is a major hindrance to the successful treatment of neoplastic disease. The development of resistance to multiple chemotherapeutic drugs is a complex phenomenon which has been described in both tumor cell lines and human cancers. To date, two mechanisms associated with overexpression of membrane glycoproteins that function as
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Expression of Multidrug Resistance-associated Protein (MRP) in Human Gliomas

Journal of Neuro-Oncology, 2000
Drug resistance is a major clinical problem in the chemotherapy of human gliomas. The multidrug resistance-associated protein (MRP), a membrane transporter related to non-P-glycoprotein multidrug resistance, is overexpressed in some drug-selected cancer cell lines. To investigate whether MRP is involved in the intrinsic drug resistance of human gliomas,
M, Mohri, H, Nitta, J, Yamashita
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Expression of multidrug resistance-associated protein (MRP) in thyroid cancers

Cancer Letters, 1995
It was found that the mechanism of anti-cancer drug resistance in anaplastic carcinoma of the thyroid was not explicable only in terms of expression of mdr1 and its gene product, P-glycoprotein. The multidrug resistance-associated protein (MRP), another member of the mdr gene family, may be involved in anti-cancer drug resistance of this carcinoma. The
I, Sugawara, A, Masunaga, S, Itoyama, T, Sumizawa, S, Akiyama, T, Yamashita   +5 more
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Topotecan Is a Substrate for Multidrug Resistance Associated Protein 4

Current Drug Metabolism, 2006
Topotecan (TPT) is a semisynthetic water-soluble derivative of camptothecin (CPT) used as second-line therapy in patients with metastatic ovarian carcinoma, small cell lung cancer, and other malignancies. However, both dose-limiting toxicity and tumor resistance hinder the clinical use of TPT. The mechanisms for resistance to TPT are not fully defined,
Quan, Tian, Jing, Zhang, Sui Yung, Chan, Theresa May Chin, Tan, Wei, Duan, Min, Huang, Yi-Zhun, Zhu, Eli, Chan, Qiang, Yu, Yu-Qiang, Nie, Paul Chi-Liu, Ho, Qi, Li, Ka-Yun, Ng, Hong-Yuan, Yang, Hong, Wei, Jin-Song, Bian, Shu-Feng, Zhou   +16 more
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[Multidrug resistance-associated proteins and their roles in multidrug resistance].

Yao xue xue bao = Acta pharmaceutica Sinica, 2013
Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. Multidrug resistance-associated proteins (MRPs) play an important role in the process of MDR. As an ATP-binding cassette (ABC) transporter superfamily, MRPs are selective and specific drug efflux pumps.
Hui, Zhang, Li-wu, Fu
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Studies on Pyrrolopyrimidines as Selective Inhibitors of Multidrug-Resistance- Associated Protein in Multidrug Resistance

Journal of Medicinal Chemistry, 2004
Multidrug resistance mediated by P-glycoprotein (Pgp) or multidrug-resistance-associated protein (MRP) remains a major obstacle for successful treatment of cancer. Inhibition of Pgp and MRP transport is important for high efficacy of anticancer drugs. While several Pgp inhibitors have entered clinical trials, the development of specific MRP1 inhibitors
Shouming, Wang, Adrian, Folkes, Irina, Chuckowree, Xiaoling, Cockcroft, Sukhjit, Sohal, Warren, Miller, John, Milton, Stephen P, Wren, Nigel, Vicker, Paul, Depledge, John, Scott, Lyndsay, Smith, Hazel, Jones, Prakash, Mistry, Richard, Faint, Deanne, Thompson, Simon, Cocks   +16 more
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Multidrug resistance associated protein 2 mediates transport of prostaglandin E₂

Liver International, 2006
Abstract: Background/Aim: Inactivation of prostaglandin E2 (PGE2) in the liver is a rapid process and occurs mainly through β‐oxidation in the peroxisome of the hepatocyte. Biliary excretion of PGE2 is also a means of elimination from the liver. We investigated the role of multidrug resistance‐associated protein 2 (MRP2) in the transport of PGE2 ...
de Waart, Dirk R., Paulusma, Coen C., Kunne, Cindy, Oude Elferink, Ronald P. J.   +3 more
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Screening method for substrates of multidrug resistance-associated protein

Analytica Chimica Acta, 2000
Abstract Multidrug resistance-associated protein (MRP) confers multidrug resistance (MDR); it transports many chemically unrelated cytotoxic reagents to the extracellular side, thereby becoming an obstacle in the chemotherapy of cancer. In this work, a simple kinetic method of analysis is presented to assay the transport selectivity of MRP for its ...
Zhe Quan, Takeaki Ozawa, Moritoshi Sato, Yoshio Umezawa   +3 more
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