Results 11 to 20 of about 150,968 (195)

Multidrug Resistance-Associated Protein 2 Deficiency Aggravates Estrogen-Induced Impairment of Bile Acid Metabolomics in Rats

Frontiers in Physiology, 2022
Multidrug resistance-associated protein 2 (Mrp2) mediates biliary secretion of anionic endobiotics and xenobiotics. Genetic alteration of Mrp2 leads to conjugated hyperbilirubinemia and predisposes to the development of intrahepatic cholestasis of ...
Fatemeh Alaei Faradonbeh, Hana Lastuvkova, Jolana Cermanova, Milos Hroch, Zuzana Nova, Martin Uher, Petra Hirsova, Petr Pavek, Stanislav Micuda   +8 more
doaj   +1 more source

Not only P-glycoprotein: amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins [PDF]

, 2017
The development of drug resistance continues to be a dominant hindrance toward curative cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and in particular of ABCB1 (P-glycoprotein or MDR1) is a well-known resistance ...
Assaraf, Yehuda G., Colotti, Gianni, Fazi, Francesco, Genovese, Ilaria, Ilari, Andrea   +4 more
core   +1 more source

Multidrug resistance-associated protein expression in clinical gastric carcinoma [PDF]

Cancer, 1996
We examined the relationship between the expression of a multi-drug resistance-associated protein (MRP) and the biologic factors regarding invasion and metastasis of human gastric cancer.In 75 patients with gastric cancer, the expression of MRP was immunohistochemically investigated and the expression of MRP mRNA was also detected using reverse ...
K, Endo, Y, Maehara, Y, Ichiyoshi, T, Kusumoto, Y, Sakaguchi, S, Ohno, K, Sugimachi   +6 more
openaire   +3 more sources

The Effects and Mechanisms of Periplaneta americana Extract Reversal of Multi-Drug Resistance in BEL-7402/5-FU Cells

Molecules, 2016
The present study reports the reversing effects of extracts from P. americana on multidrug resistance of BEL-7402/5-FU cells, as well as a preliminary investigation on their mechanism of action.
Falu Yuan, Junyong Liu, Tingting Qiao, Ting Li, Qi Shen, Fang Peng   +5 more
doaj   +1 more source

Multidrug-resistance proteins are weak tumor associated antigens for colorectal carcinoma

BMC Immunology, 2011
Background Multidrug resistance (MDR) is a clinically, highly relevant phenomenon. Under chemotherapy many tumors show an increasing resistance towards the applied substance(s) and to a certain extent also towards other agents.
Linnebacher Michael, Klar Ernst, Eisold Sven, Mullins Christina S   +3 more
doaj   +1 more source

Detection of Multidrug-Resistant RND Efflux Pumps and Regulatory Proteins in Antibiotic-Resistant P. aeruginosa Recovered from Hospital Wastewater Effluent in the Eastern Cape Province of South Africa

Applied Sciences, 2023
P. aeruginosa (P. aeruginosa) is a problematic hospital agent that is a global challenge due to the ineffectiveness of some conventional antimicrobial therapies. Multidrug-resistant (MDR) P.
Joan U. Okafor, Uchechukwu U. Nwodo
doaj   +1 more source

ATPase Activity of Purified Multidrug Resistance-associated Protein [PDF]

Journal of Biological Chemistry, 1997
Human multidrug resistance protein (MRP) was expressed at high levels in stably transfected baby hamster kidney (BHK-21) cells. These cells exhibited a pattern of cross-resistance to several different drugs typical of an MRP-mediated phenotype despite the addition of 10 histidine residues at the C terminus to facilitate purification.
X B, Chang, Y X, Hou, J R, Riordan
openaire   +2 more sources

Comparative transcriptomics of multidrug-resistant Acinetobacter baumannii in response to antibiotic treatments [PDF]

, 2018
Multidrug-resistant Acinetobacter baumannii, a major hospital-acquired pathogen, is a serious health threat and poses a great challenge to healthcare providers.
Chan, Ting-Fung, Fong-Chuen Loo, Jacky, Ip, Margaret, Lau, Terrence Chi-Kong, Lin, Xiao, Qin, Hao, Tsui, Stephen Kwok-Wing, Wai-Sing Lo, Norman, Yim, Aldrin Kay-Yuen   +8 more
core   +2 more sources

An ace up their sleeve: a transcriptomic approach exposes the AceI efflux protein of Acinetobacter baumannii and reveals the drug efflux potential hidden in many microbial pathogens

Frontiers in Microbiology, 2015
The era of antibiotics as a cure-all for bacterial infections appears to be coming to an end. The emergence of multidrug resistance in many hospital-associated pathogens has resulted in superbugs that are effectively untreatable.
Karl A Hassan, Liam DH Elbourne, Liping eLi, Hasinika KA Hewawasam Gamage, Qi eLiu, Scott M Jackson, David eSharples, Anne-Brit eKolstø, Peter JF Henderson, Ian T Paulsen   +9 more
doaj   +1 more source

Global protein responses of multidrug resistance plasmid-containing Escherichia coli to ampicillin, cefotaxime, imipenem and ciprofloxacin

Journal of Global Antimicrobial Resistance, 2022
: Objectives: This study compared the proteomics of Escherichia coli containing the multidrug resistance plasmid pEK499 under antimicrobial stress and with no antimicrobial.
Anatte Margalit, James C. Carolan, Fiona Walsh   +2 more
doaj   +1 more source