Results 41 to 50 of about 150,968 (195)

The role of photodynamic therapy on multidrug resistant breast cancer

Cancer Cell International, 2019
Breast cancer heterogeneity allows cells with different phenotypes to co-exist, contributing to treatment failure and development of drug resistance. In addition, abnormal signal transduction and dysfunctional DNA repair genes are common features with ...
Eric Chekwube Aniogo, Blassan Plackal Adimuriyil George, Heidi Abrahamse   +2 more
doaj   +1 more source

Expression and clinical significance of multidrug resistance proteins in brain tumors

Journal of Experimental & Clinical Cancer Research, 2010
Background To investigate the mechanisms of multidrug resistance of brain tumors, to identify the site of cellular expression of P-gp in human brains in situ and to morphologically determine whether an association may exist between P-gp and caveolin-1 ...
Guo Zhenhua, Zhu Jin, Zhao Lihua, Luo Qing, Jin Xianqing   +4 more
doaj   +1 more source

Investigating the role of Hedgehog/GLI1 signaling in glioblastoma cell response to temozolomide. [PDF]

, 2018
Resistance to chemotherapy substantially hinders successful glioblastoma (GBM) treatment, contributing to an almost 100% mortality rate. Resistance to the frontline chemotherapy, temozolomide (TMZ), arises from numerous signaling pathways that are ...
Day, Emily S, Gleghorn, Jason P, Ioele, Stephen A, Melamed, Jilian R, Morgan, Joshua T, Sims-Mourtada, Jennifer   +5 more
core   +1 more source

Investigating bacteriophages targeting the opportunistic pathogen Acinetobacter baumannii [PDF]

, 2020
The multi-drug resistance of the opportunistic pathogen Acinetobacter baumannii is of growing concern, with many clinical isolates proving to be resistant to last resort as well as front line antibiotic treatments.
Christie, Gabrielle S., Dowson, Christopher G., Leungtongkam, Udomluk, Millard, Andrew D., Moat, John, Sagona, Antonia P., Sitthisak, Sutthirat, Smith, Sophie, Styles, Kathryn, Thummeepak, Rapee, Wellington, Elizabeth M. H.   +10 more
core   +1 more source

The porin and the permeating antibiotic: A selective diffusion barrier in gram-negative bacteria [PDF]

, 2008
Gram-negative bacteria are responsible for a large proportion of antibiotic resistant bacterial diseases. These bacteria have a complex cell envelope that comprises an outer membrane and an inner membrane that delimit the periplasm.
A Baslé, A Baslé, A Bryskier, A Davin-Regli, A Davin-Régli, A Doménech-Sánchez, A Doménech-Sánchez, A Loli, A Mena, A Mena, A Prilipov, A Thiolas, A Thiolas, AA Medeiros, AH Delcour, AM Berezhkovskii, AM Giuliodori, AS Low, C Bornet, C Bornet, C Bosi, C Danelon, C Danelon, C Rodrigues, C Sheridan, Chloë E. James, D Jeanteur, D Szabó, DJ Wolter, E Dé, E Elliott, E Sugawara, EM Nestorovich, EM Nestorovich, F Yoshimura, FM Kaczmarek, G Schwarz, GA Jacoby, GE Schulz, H Nikaido, H Nikaido, H Nikaido, H Samartzidou, H Samartzidou, J Bredin, J Chevalier, J Chevalier, J-M Pagès, JC Cai, Jean-Marie Pagès, JM Bower, K Poole, L Kullman, L Martínez-Martínez, LB Rice, LJ Piddock, LP Randall, M Ceccarelli, M Guillier, M Luckey, M Malléa, M Olesky, M Olesky, M Viveiros, MA Kohanski, Mathias Winterhalter, MM Ochs, N El Amin, P Valentin-Hansen, R Dutzler, R Iyer, R Iyer, R Koebnik, RE Hancock, RN Charrel, S Biswas, S Blot, S Hernández-Allés, S Hernández-Allés, S Nekolla, S Vidal, S Vidal, SF Epp, SM Bezrukov, SM Bezrukov, SR Norrby, SW Cowan, T Ferenci, T Mach, UO Hasdemir, V Simonet, V Simonet, WL Veal, WM Shafer, WR Bauer, XZ Li   +95 more
core   +1 more source

Interaction of Oxazaphosphorines with Multidrug Resistance-Associated Protein 4 (MRP4) [PDF]

The AAPS Journal, 2010
Multidrug resistance-associated protein 4 (MRP4) is an organic anion efflux pump capable of transporting nucleoside, nucleotide analogs, and cyclic nucleotide. MRP4 could have an influence on the resistance and transport of the two oxazaphosphorines, cyclophosphamide (CP) and ifosfamide (IF).
Zhang, J., Ng, K.-Y., Ho, P.C.
openaire   +2 more sources

A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship [PDF]

, 2007
We undertook a systematic review of the pre-clinical and clinical literature for studies investigating the relationship between platinum and taxane resistance.
Davey, Ross, Pavlakis, Nick, Stordal, Britta   +2 more
core   +1 more source

Quercetin Suppresses CYR61-Mediated Multidrug Resistance in Human Gastric Adenocarcinoma AGS Cells

Molecules, 2018
Cysteine-rich angiogenic inducer 61 (CYR61) is an extracellular matrix-associated protein involved in survival, tumorigenesis, and drug resistance. Therefore, we examined the effects of flavones against CYR61-overexpressing human gastric adenocarcinoma ...
Ho Bong Hyun, Jeong Yong Moon, Somi Kim Cho   +2 more
doaj   +1 more source

CORRELATION BETWEEN CHEMOTHERAPY RESPONSE AND EXPRESSION PROFILES OF TRANSMEMBRANE PROTEINS: P-GLYCOPROTEIN (ABCB1), MRP2 (ABCC2), BCRP (ABCG2) IN PATIENTS WITH INVASIVE BREAST CANCER

Сибирский онкологический журнал, 2016
Overexpression of ABC drug transporters can cause multidrug resistance (MDR) in cancer cells, which is a major obstacle in the success of cancer chemotherapy.
К. Yu. Khristenko, S. V. Vtorushin, М. V. Zavjalova, V. M. Perelmuter   +3 more
doaj   +1 more source

Exploring Virulence Factors and Alternative Therapies against Staphylococcus aureus Pneumonia

Toxins, 2020
Pneumonia is an acute pulmonary infection associated with high mortality and an immense financial burden on healthcare systems. Staphylococcus aureus is an opportunistic pathogen capable of inducing S.
Jelle Vlaeminck, Dina Raafat, Kristin Surmann, Leen Timbermont, Nicole Normann, Bret Sellman, Willem J. B. van Wamel, Surbhi Malhotra-Kumar   +7 more
doaj   +1 more source