Results 51 to 60 of about 150,968 (195)
A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins [PDF]
JNCI Journal of the National Cancer Institute, 2000 The human multidrug resistance-associated protein (MRP) family currently has seven members. The ability of several of these membrane proteins to transport a wide range of anticancer drugs out of cells and their presence in many tumors make them prime suspects in unexplained cases of drug resistance, although proof that they contribute to clinical drug ...
P, Borst +3 more
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Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta [PDF]
, 2017 Preventive chemotherapy has long been practiced against nematode parasites of livestock, leading to widespread drug resistance, and is increasingly being adopted for eradication of human parasitic nematodes even though it is similarly likely to lead to ...
Bisset, Stewart A +6 more
core +4 more sources
Frontiers in Pharmacology, 2022 Rifampicin (RIF) is a critical first-line drug for tuberculosis. However, long-term or high-dose treatment with RIF can induce severe liver injury; the underlying mechanism of this effect has not yet been clarified.
Yang Deng +9 more
doaj +1 more source
Energetics and Mechanism of Drug Transport Mediated by the Lactococcal Multidrug Transporter LmrP [PDF]
, 1996 The gene encoding the secondary multidrug transporter LmrP of Lactococcus lactis was heterologously expressed in Escherichia coli. The energetics and mechanism of drug extrusion mediated by LmrP were studied in membrane vesicles of E. coli. LmrP-mediated
Bolhuis, Henk, +6 more
core +1 more source
Cyclooxygenases and Lipoxygenases in Cancer Drug Resistance
Gazi Medical JournalCancer drug resistance is a critical factor restricting the success rate of chemotherapeutics. Alterations in both cellular and systemic mechanisms could induce drug resistance in cancer. At the cellular level, numerous pathways have been associated with
Hasan Hüseyin Kazan +2 more
doaj +1 more source
PLoS ONE, 2013 Overexpression of multidrug transporters is a well-established mechanism of resistance to chemotherapy, but other changes may be co-selected upon exposure to drugs that contribute to resistance.
Nancy E Caceres +6 more
doaj +1 more source
Crystal structures of two transcriptional regulators from Bacillus cereus define the conserved structural features of a PadR subfamily. [PDF]
PLoS ONE, 2012 PadR-like transcriptional regulators form a structurally-related family of proteins that control the expression of genes associated with detoxification, virulence and multi-drug resistance in bacteria.
Guntur Fibriansah +5 more
doaj +1 more source
Glutathione Export during Apoptosis Requires Functional Multidrug Resistance-associated Proteins [PDF]
Journal of Biological Chemistry, 2007 GSH is released in cells undergoing apoptosis, and the present study indicates that the multidrug resistance-associated proteins (MRPs/ABCC) are responsible for this GSH release. Jurkat cells released approximately 75-80% of their total intracellular GSH during both Fas antibody- and staurosporine-induced apoptosis.
Christine L, Hammond +3 more
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Social interactions in the Burkholderia cepacia complex : biofilms and quorum sensing [PDF]
, 2010 Burkholderia cepacia complex bacteria are opportunistic pathogens that cause respiratory tract infections in susceptible patients, mainly people with cystic fibrosis. There is convincing evidence that B.
Coenye, Tom
core +2 more sources
Emtricitabine: Inhibitor and substrate of multidrug resistance associated protein
European Journal of Pharmaceutical Sciences, 2008 Efflux proteins have been shown to greatly affect the uptake of antiretroviral drugs by cells and to prevent their access to the HIV-1 replication site. The active efflux of these drugs might produce subtherapeutic drug levels and favor resistant viral strains and the emergence of sanctuary sites.
Laurence, Bousquet +4 more
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