Results 81 to 90 of about 150,968 (195)

Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain [PDF]

, 2017
There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including autism, neonatal seizures, and epilepsy, which are not related to its effects on the kidney but ...
Erker, Thomas, Fedrowitz, Maren, Hampel, Philip, Kaczmarek, Edith, Löscher, Wolfgang, Römermann, Kerstin, Sweet, Douglas H., Töllner, Kathrin   +7 more
core   +2 more sources

In vitro activity of curcumin in combination with epigallocatechin gallate (EGCG) versus multidrug-resistant Acinetobacter baumannii [PDF]

, 2014
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Betts, JW, Wareham, DW
core   +2 more sources

Indole contributes to tetracycline resistance via the outer membrane protein OmpN in Vibrio splendidus [PDF]

, 2020
As an interspecies and interkingdom signaling molecule, indole has recently received attention for its diverse effects on the physiology of both bacteria and hosts. In this study, indole increased the tetracycline resistance of Vibrio splendidus.
Guo, Ming, Li, Chenghua, Lv, Zhimeng, Shao, Yina, Zhang, Shanshan, Zhang, Weiwei, Zhao, Xuelin   +6 more
core   +1 more source

In-depth analysis of the treatment effect and synergistic mechanism of TanReQing injection on clinical multi-drug resistant Pseudomonas aeruginosa

Microbiology Spectrum
Antibiotic resistance is a recognized and concerning public health issue. Gram-negative bacilli, such as Pseudomonas aeruginosa (P. aeruginosa), are notorious for their rapid development of drug resistance, leading to treatment failures.
Dongying Li, Yueyi Li, Jingyi Wang, Weifeng Yang, Kaiyu Cui, Renjing Su, Lu Li, Xing Ren, Xianyu Li, Yi Wang   +9 more
doaj   +1 more source

Acinetobacter baumannii: Mechanisms of Antimicrobial Resistance

Антибиотики и Химиотерапия
Gram-negative non-fermenting bacteria Acinetobacter baumannii are a common cause of severe complications (pneumonia, bacteremia, sepsis) in the clinic of internal diseases, especially in patients with weakened immune system: 3,2% of bacteremia and sepsis
N. E. Barantsevich, L. V. Ivanova, E. P. Barantsevich   +2 more
doaj   +1 more source

DNA repair systems and the pathogenesis of Mycobacterium tuberculosis: varying activities at different stages of infection [PDF]

, 2010
Mycobacteria, including most of all MTB (Mycobacterium tuberculosis), cause pathogenic infections in humans and, during the infectious process, are exposed to a range of environmental insults, including the host's immune response.
Adams, Afanasev, Alina E. Gorna, Aly, Arnold, Bacon, Banu, Bergval, Betts, Boshoff, Boshoff, Bostanabad, Burney, Capelli, Chan, Chan, Cheng, Cooper, Cubillos-Ruiz, Darwin, Darwin, Das, Davis, Dos Vultos, Dubnau, Durbach, Farnia, Fennelly, Filliol, Fleischmann, Flint, Fontan, Friedberg, Frischkorn, Fu, Fu, Gaynor, Gordhan, Graham, Grishko, Guthlein, Hampshire, Hazbon, Hughes, Jain, Jaroslaw Dziadek, Jiao, Kapur, Karakousis, Karakousis, Karunkaran, Katti, Kesavan, Kim, Ko, Ko, Korycka-Machala, Krokan, Kurthkoti, Kurthkoti, Lari, Lever, Loudon, MacMicking, Malshetty, Martinez, Mokrousov, Moller, Movahedzadeh, Mulder, Munoz-Elias, Muttucumaru, Nguyen, Niemann, Nikolayevskyy, Nouvel, O'sullivan, Olano, Peccia, Peccia, Pitcher, Rachman, Rachman, Rad, Ramaswamy, Richard P. Bowater, Riley, Saito, Sander, Sassetti, Sassetti, Saunders, Schnappinger, Schwab, Sherman, Sinha, Sinha, Smeulders, Springer, Srivastava, Stephanou, Talaat, Talaat, Tang, Tsai, Venkatesh, Vilcheze, Voskuil, Voskuil, Waddell, Wanner, Warner, Weikert, Wiid, Wiseman, World Health Organization, Zaczek, Zainuddin   +117 more
core   +1 more source

Expression of P-glycoprotein, multidrug resistance-associated protein, glutathione-S-transferase pi and p53 in canine transmissible venereal tumor

Pesquisa Veterinária Brasileira, 2014
The overexpression of proteins P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP1), mutant p53, and the enzyme glutathione-S-transferase (GSTpi) are related to resistance to chemotherapy in neoplasms. This study evaluated the expression
Daniel G. Gerardi, Mirela Tinucci-Costa, Ana Carolina T. Silveira, Juliana V. Moro   +3 more
doaj   +1 more source

An Arabidopsis flavonoid transporter is required for anther dehiscence and pollen development [PDF]

, 2010
FLOWER FLAVONOID TRANSPORTER (FFT) encodes a multidrug and toxin efflux family transporter in Arabidopsis thaliana. FFT (AtDTX35) is highly transcribed in floral tissues, the transcript being localized to epidermal guard cells, including those of the ...
Aarts, Beverley J. Glover, Blankenship, Bolhar-Nordenkampf, Broun, Buer, Buer, Burbulis, Bush, Cecchetti, Christopher Wilkins, Church, Davis, Debeaujon, Debeaujon, Debeaujon, Diener, Durkee, Elinor P. Thompson, Gilmartin, Gitz, Gomez, Goodman, Green, Hideg, Higo, Hipkins, Hutzler, Ishida, Jacobs, Jaquinod, Jefferson, Jones, Julia M. Davies, Jung, Keijzer, Kerhoas, Kitamura, Koornneef, Lazar, Li, Macquet, Marinova, Mathews, Matsumoto, Mitsuda, Morant, Napoli, Nawrath, Nicolson, Omote, Peer, Peer, Peer, Pelletier, Pfündel, Pline, Porra, Preston, Rogers, Rohde, Routaboul, Sablowski, Sambrook, Sanders, Saslowsky, Scott, Shirley, Shirley, Taylor, Uhde-Stone, Vadim Demidchik, Walker, Xie, Zhao   +74 more
core   +2 more sources

Expression of multidrug resistance-1 and multidrug resistance-associated protein genes in pediatric rhabdomyosarcoma

Oncology Reports, 2004
Overexpression of multidrug resistance-1 (MDR-1), and multidrug resistance-associated protein (MRP) genes has been linked with resistance to chemotherapy in vitro and in vivo. Their role in chemotherapy resistance in pediatric rhabdomyosarcoma is unclear. The study was undertaken to analyze the expression of MDR-1 and MRP genes in the embryonal and the
Gallego S, Llort A, Parareda A, Sanchez De Toledo J   +3 more
openaire   +4 more sources

Molecular Mechanisms Used by Salmonella to Evade the Immune System [PDF]

, 2017
Human and animal pathogens are able to circumvent, at least temporarily, the sophisticated immune defenses of their hosts. Several serovars of the Gram-negative bacterium Salmonella enterica have been used as models for the study of pathogen-host ...
Bernal Bayard, Joaquín, Ramos Morales, Francisco   +1 more
core   +1 more source