Results 121 to 130 of about 18,450 (254)

Efficient Production of L-Threonine by E. coli Using High-Throughput Screening and Multi-Enzyme Complex Engineering

Fermentation
To enhance the L-threonine synthesis level in Escherichia coli, this study constructed screening markers rich in L-threonine rare codons. By replacing all the threonine codons in the protein sequences with a high proportion of threonine with L-threonine ...
Chuanzhuang Guo, Nan Li, Lu Yang, Jianbin Wang, Junlin Li, Piwu Li, Junqing Wang, Ruiming Wang   +7 more
doaj   +1 more source

Immunological and biosynthetic studies on the mammalian 2‐oxoglutarate dehydrogenase multienzyme complex [PDF]

, 1986
Anne Hunter, J. Gordon Lindsay
openalex   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, Volume 59, Issue 2, February 2026.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

Low immunogenicity of the common lipoamide dehydrogenase subunit (E3) of mammalian pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multienzyme complexes [PDF]

, 1985
Olga L. De Marcucci, A.G.W. Hunter, J. Gordon Lindsay   +2 more
openalex   +1 more source

Bidirectional Communication Between Astrocytes and Neurons via Extracellular Vesicles: A Multi‐Omics Approach

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Schematic diagram illustrating the communication between mouse hippocampal astrocytes and neurons through extracellular vesicles (EVs). The illustration highlights unique proteins secreted by each cell type within EVs, with vesicle size proportional to the concentration of secreted proteins.
Daria Hajka, Paulina Żebrowska‐Różańska, Katarzyna Romańczuk, Jacek R. Wiśniewski, Łukasz Łaczmański, Norbert Łodej, Krzysztof J. Pawlik, Dariusz Rakus, Agnieszka Gizak   +8 more
wiley   +1 more source

Carbohydrate restriction drives greater perturbations in circulating metabolites than low energy availability in elite male athletes

Physiological Reports, Volume 14, Issue 3, February 2026.
Elite male race walkers underwent a 5 d dietary intervention of either high carbohydrate (HCHO), low‐carbohydrate high‐fat (LCHF), or low energy availability (LEA) to evaluate their metabolomic response. Following a standardized 25 km endurance walk, blood samples were collected across five timepoints, ranging from a fasted state to 3 h post‐exercise ...
Kyle A. Dunlop, Nathan G. Lawler, Jamie Whitfield, Alannah K. A. McKay, Nicolin Tee, Megan L. Ross, Stacey N. Reinke, John A. Hawley, David Broadhurst, Louise M. Burke   +9 more
wiley   +1 more source

Design of a Multienzyme Derived from Mouse Fatty Acid Synthase for the Compartmentalized Production of 2‐Pyrone Polyketides

Angewandte Chemie International Edition, Volume 65, Issue 2, 9 January 2026.
A multienzyme was formed and evaluated by covalently linking 4‐coumarate ligase (4CL1) from Piper methysticum to a non‐reducing murine fatty acid synthase. 4CL1 acylates the acyl carrier protein (ACP). The ketosynthase (KS) was engineered to accept the non‐native cinnamoyl substrate, which is elongated by malonyl‐CoA loaded via the malonyl‐acetyl ...
Felix Lehmann, Nadja Joachim, Carolin Parthun, Martin Grininger   +3 more
wiley   +1 more source

Evolutionary analysis of the TPP-dependent enzyme family [PDF]

, 2008
The evolutionary relationships of the thiamine pyrophosphate (TPP)-dependent family of enzymes was investigated by generation of a neighbor joining phylogenetic tree using sequences from the conserved pyrophosphate (PP) and pyrimidine (Pyr) binding ...
Costelloe, S.J., Dalby, P.A., Ward, J.M.
core  

Polyhydroxybutyrate accumulation by a Serratia sp [PDF]

, 2008
A strain of Serratia sp. showed intracellular electron-transparent inclusion bodies when incubated in the presence of citrate and glycerol 2-phosphate without nitrogen source following pregrowth under carbon-limitation in continuous culture.
Hewitt, CJ, Jenkins, M, Kashani, M, Lugg, H, Macaskie, LE, Marquis, PM, Paterson-Beedle, M, Redwood, MD, Sammons, RL, Stamboulis, A, Yong, P   +10 more
core  

Functional properties, structural studies and chemoenzymatic synthesis of oligosaccharides [PDF]

Oligosaccharides offer beneficial effects on immune system and gut health, such as anticancer activity, immunomodulatory activity, and complement activation. Functional oligosaccharides are widely found in plants, algae, bacteria and higher fungi.
Cao, H, Liu, B, Liu, X, Nahar, L, Sarker, SD, Wu, Y, Yu, H, Zhao, C   +7 more
core   +1 more source