Results 51 to 60 of about 6,631,648 (289)

The dynamic organization of fungal acetyl-CoA carboxylase [PDF]

, 2016
Acetyl-CoA carboxylases (ACCs) catalyse the committed step in fatty-acid biosynthesis: the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. They are important regulatory hubs for metabolic control and relevant drug targets for the treatment of ...
Hagmann, Anna, Hunkeler, Moritz, Imseng, Stefan, Maier, Timm, Stuttfeld, Edward   +4 more
core   +1 more source

Protein kinase A (PKA) phosphorylation of Shp2 inhibits its phosphatase activity and modulates ligand specificity. [PDF]

, 2015
Pathological cardiac hypertrophy (an increase in cardiac mass resulting from stress-induced cardiac myocyte growth) is a major factor underlying heart failure.
Burmeister, BT, Carnegie, GK, Gold, MG, O'Bryan, JP, Skidgel, RA, Wang, L   +5 more
core   +1 more source

Transcriptome Analysis of Cyclooctasulfur Oxidation and Reduction by the Neutrophilic Chemolithoautotrophic Sulfurovum indicum from Deep-Sea Hydrothermal Ecosystems

Antioxidants, 2023
Chemolithoautotrophic Campylobacterota are widespread and predominant in worldwide hydrothermal vents, and they are key players in the turnover of zero-valence sulfur.
Shasha Wang, Lijing Jiang, Liang Cui, Karine Alain, Shaobin Xie, Zongze Shao   +5 more
doaj   +1 more source

Assembly of Xylanases into Designer Cellulosomes Promotes Efficient Hydrolysis of the Xylan Component of a Natural Recalcitrant Cellulosic Substrate

mBio, 2011
In nature, the complex composition and structure of the plant cell wall pose a barrier to enzymatic degradation. Nevertheless, some anaerobic bacteria have evolved for this purpose an intriguing, highly efficient multienzyme complex, the cellulosome ...
Sarah Moraïs, Yoav Barak, Yitzhak Hadar, David B. Wilson, Yuval Shoham, Raphael Lamed, Edward A. Bayer   +6 more
doaj   +1 more source

Membrane-enclosed multienzyme (MEME) synthesis of 2,7-anhydro-sialic acid derivatives [PDF]

, 2017
Naturally occurring 2,7-anhydro-alpha-N-acetylneuraminic acid (2,7-anhydro-Neu5Ac) is a transglycosylation product of bacterial intramolecular trans-sialidases (IT-sialidases).
Andrew Bell, Angata, Bednarski, Chen, Chokhawala, Chokhawala, Crost, Crost, Dimitrios Latousakis, Etzold, Furuhata, Gerardy-Schahn, Gwenaelle Le Gall, Hai Yu, Ian J. Colquhoun, Juge, Juge, Lee, Lewis, Li, Li, Lifely, Louise E. Tailford, Luo, Luo, Marie Monestier, Martin Rejzek, Nathalie Juge, Ouwerkerk, Robert A. Field, Rohrer, Sandra Tribolo, Savage, Schauer, Schroder, Simone Dedola, Suzuki, Tailford, Tailford, Varki, Xi Chen, Yu   +41 more
core   +2 more sources

Designer cellulosomes – catalytic nanomachines with significant potential in biotechnology and circular economy

Acta Biologica Slovenica
Cellulosomes are multienzyme complexes originally found on the surface of certain anaerobic celluloytic bacteria and fungi that are specialized in the degradation of plant cell walls.
Maša Vodovnik
doaj   +1 more source

Controlled Orientation of Active Sites in a Nanostructured Multienzyme Complex [PDF]

, 2016
Multistep cascade reactions in nature maximize reaction efficiency by co-assembling related enzymes. Such organization facilitates the processing of intermediates by downstream enzymes.
A Sachdeva, A Weckbecker, BM Hutchins, CC Roberts, CH Kim, CJ Delebecque, D Guan, DE Torres Pazmino, EM Brustad, H Choe, H Nanba, H Pettersson, HS Seo, J Fu, J Fu, J-L Lin, JA Johnson, JE Dueber, JW Chin, M Castellana, M Leibundgut, M Slatner, MG Hoesl, MH Seo, MJ Lajoie, ML Blackman, NJ Agard, O Idan, P Bauler, P Brunker, P Bubner, R Narayanaswamy, RJ Conrado, S An, S Schoffelen, SI Lim, SI Lim, SI Lim, SI Lim, SR Bond, TM Schmeing, TS Moon, Y Kim, Y Zhang   +43 more
core   +2 more sources

Lipoate-binding proteins and specific lipoate-protein ligases in microbial sulfur oxidation reveal an atpyical role for an old cofactor

eLife, 2018
Many Bacteria and Archaea employ the heterodisulfide reductase (Hdr)-like sulfur oxidation pathway. The relevant genes are inevitably associated with genes encoding lipoate-binding proteins (LbpA).
Xinyun Cao, Tobias Koch, Lydia Steffens, Julia Finkensieper, Renate Zigann, John E Cronan, Christiane Dahl   +6 more
doaj   +1 more source

Comparative genomic analysis reveals 2-oxoacid dehydrogenase complex lipoylation correlation with aerobiosis in archaea. [PDF]

PLoS ONE, 2014
Metagenomic analyses have advanced our understanding of ecological microbial diversity, but to what extent can metagenomic data be used to predict the metabolic capacity of difficult-to-study organisms and their abiotic environmental interactions?
Kirill Borziak, Mareike G Posner, Abhishek Upadhyay, Michael J Danson, Stefan Bagby, Steve Dorus   +5 more
doaj   +1 more source

A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids. [PDF]

Adv Sci (Weinh)
A simplified chemoenzymatic platform is designed to integrate an enzyme cascade with subsequent chemical steps, enabling the divergent production of diverse benzylisoquinoline alkaloids (BIAs). Demonstrating remarkable versatility and enantioselectivity, four distinct classes of BIAs are efficiently generated, in which the natural medicine papaverine ...
Liu H, Yuan Z, Gao Y, Li F, Deng Z, Zhang Y, Luo Z, Liu C, Rao Y.   +8 more
europepmc   +2 more sources