Results 51 to 60 of about 928,687 (218)

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

The glycine decarboxylase complex multienzyme family in Populus [PDF]

Journal of Experimental Botany, 2007
In plants, the glycine decarboxylase complex (GDC) cooperates with serine hydroxymethyltransferase (SHMT) to mediate photorespiratory glycine-serine interconversion. GDC is also postulated to be an integral component of one-carbon (C1) metabolism in heterotrophic tissues, although molecular evidence in plants is scarce.
Mohan, Rajinikanth, Scott A, Harding, Chung-Jui, Tsai   +2 more
openaire   +2 more sources

Pyruvate dehydrogenase : its structure, function and interactions within the pyruvate dehydrogenase multienzyme complex [PDF]

, 2002
Pyruvate dehydrogenase multi-enzyme complex (PDHC) is member of a family of multienzyme complexes that catalyse the irreversible decarboxylation of various 2-oxoacid substrates to their corresponding acyl-CoA derivatives, NADH and C02.
Hengeveld, A.F.
core  

Cascade Biocatalysis by Multienzyme–Nanoparticle Assemblies

, 2016
Multienzyme complexes are of paramount importance in biosynthesis in cells. Yet, how sequential enzymes of cascade catalytic reactions synergize their activities through spatial organization remains elusive.
Jiang Xia (724344), Yunyu Nie (1368768), Jianpeng Wang (724341), Zhihong Guo (404198), Wei Kang (175399), Jiahui Liu (724342)   +5 more
core   +1 more source

Lipoate-binding proteins and specific lipoate-protein ligases in microbial sulfur oxidation reveal an atpyical role for an old cofactor

eLife, 2018
Many Bacteria and Archaea employ the heterodisulfide reductase (Hdr)-like sulfur oxidation pathway. The relevant genes are inevitably associated with genes encoding lipoate-binding proteins (LbpA).
Xinyun Cao, Tobias Koch, Lydia Steffens, Julia Finkensieper, Renate Zigann, John E Cronan, Christiane Dahl   +6 more
doaj   +1 more source

Coordination‐Tuned Iridium Single‐Atom Nanozymes Boost Multienzyme Activity for Colorimetric Sensing

Advanced Science, EarlyView.
Breaking the coordination symmetry of Ir single‐atom sites through asymmetric Ir–N3S1 engineering tailors interfacial electron transfer, oxygen activation, and multienzyme‐like catalytic pathways. Operando spectroscopy and theoretical modeling uncover the atomic‐level origin of activity enhancement, providing a strategy for designing multifunctional ...
Tao Li, Xinyu Zhang, Jiashan Xia, Mengyu Wu, Cong Liu, Yapei Sun, Wanjiang Zhao, Min Qian, Wei Wang, Weixia Duan, Shangcheng Xu   +10 more
wiley   +1 more source

The Molecular Origins of Specificity in the Assembly of a Multienzyme Complex [PDF]

Structure, 2005
The pyruvate dehydrogenase (PDH) multienzyme complex is central to oxidative metabolism. We present the first crystal structure of a complex between pyruvate decarboxylase (E1) and the peripheral subunit binding domain (PSBD) of the dihydrolipoyl acetyltransferase (E2).
Frank, René A.W., Pratap, J. Venkatesh, Pei, Xue Y., Perham, Richard N., Luisi, Ben F.   +4 more
openaire   +2 more sources

Comparative genomic analysis reveals 2-oxoacid dehydrogenase complex lipoylation correlation with aerobiosis in archaea. [PDF]

PLoS ONE, 2014
Metagenomic analyses have advanced our understanding of ecological microbial diversity, but to what extent can metagenomic data be used to predict the metabolic capacity of difficult-to-study organisms and their abiotic environmental interactions?
Kirill Borziak, Mareike G Posner, Abhishek Upadhyay, Michael J Danson, Stefan Bagby, Steve Dorus   +5 more
doaj   +1 more source

Magneto‐NIR‐II‐Programmed Cascade Nanozymes Unlocking Blood–Brain Barrier Translocation and Autophagic Resistance in Glioblastoma

Advanced Science, EarlyView.
Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu, Yundi Wu, Shuai Zhang, Hongjuan Zhao, Jiping Zheng, Shiyang Shao, Jianqiang Chen, Xilong Wu   +7 more
wiley   +1 more source

Regulation of Brain Pyruvate Dehydrogenase Multienzyme Complex [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1978
SUMMARY:A number of excellent and comprehensive reviews on various aspects of pyruvate dehydrogenase multienzyme complex have been written recently. The purpose of the present review is to summarize briefly the reaction mechanism and the regulation of this enzyme. Emphasis is put on the most recent literature not covered by previous reviews. Particular
T T, Ngo, A, Barbeau
openaire   +2 more sources