Results 81 to 90 of about 8,722 (211)

From Cold to Hot: Nanozyme‐Based Strategies for Reprogramming the Tumour Immunoenvironment

Cell Proliferation, EarlyView.
Nanozymes, with multi‐enzyme catalytic activities, reprogram the immunosuppressive tumour microenvironment by inducing immunogenic cell death, relieving hypoxia, and depleting antioxidants, effectively converting immunologically “cold” tumours into “hot” ones to boost cancer immunotherapy efficacy.
Yue Wang, Miao Xu, Yongshun Wang, Xuan Lin, Qiang Zhang, Xiaoning Lin, Xin Wu, Cheng Zhang, Wenhua Huang, Jianlin Shen   +9 more
wiley   +1 more source

Secretomic analyses of Ruminiclostridium papyrosolvens reveal its enzymatic basis for lignocellulose degradation

Biotechnology for Biofuels, 2019
Background Efficient biotechnological conversion of lignocellulosic biomass to valuable products, such as transportation biofuels, is ecologically attractive, yet requires substantially improved mechanistic understanding and optimization to become ...
Zhenxing Ren, Wuxin You, Shasha Wu, Ansgar Poetsch, Chenggang Xu   +4 more
doaj   +1 more source

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

Experimental Physiology, EarlyView.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer, Dena Lin, Alec Hanshew, Jackson Stewart, Steven Ball, Christa Lilly, Saina S. Prabhu, Kate Karelina, Eric E. Kelley, Randy W. Bryner, Dharendra Thapa, Paul D. Chantler   +11 more
wiley   +1 more source

Heterozygous OGDH Variants Are Involved in Peripheral Neuropathy With Ataxia and Optical Atrophy

JIMD Reports, Volume 67, Issue 4, July 2026.
ABSTRACT 2‐oxyglutarate dehydrogenase (OGDH) encodes an E1 component of α‐ketoglutarate dehydrogenase complex that plays a pivotal role in the Krebs cycle. Biallelic variants in OGDH have been reported to cause an early‐onset neurodevelopmental and mitochondrial disorder.
Liedewei Van de Vondel, Gyu S. Lee, Jonathan De Winter, Satoshi Matsuzaki, Abigail Sandoval, Juan Felipe Ramirez, Alice Monticelli, Sukyeong Lee, Rita Horvath, Jan de Bleecker, Stephan Züchner, Kenneth M. Humphries, Jonathan Baets, Wan Hee Yoon   +13 more
wiley   +1 more source

Species of family Promicromonosporaceae and family Cellulomonadeceae that produce cellulosome-like multiprotein complexes

, 2018
To screen the phylogenetically-nearest members of Cellulosimicrobium cellulans for the production of cellulosome-like multienzyme complexes and extracellular beta-xylosidase activity against 7-xylosyltaxanes and to get corresponding molecular ...
Wang, Jia-Yue, Yu, Yang, Wang, Wei, Dou, Tong-Yi, Sun, Chenggong   +4 more
core   +1 more source

Adaptor Scaffoldins: An Original Strategy for Extended Designer Cellulosomes, Inspired from Nature

mBio, 2016
Designer cellulosomes consist of chimeric cohesin-bearing scaffoldins for the controlled incorporation of recombinant dockerin-containing enzymes. The largest designer cellulosome reported to date is a chimeric scaffoldin that contains 6 cohesins.
Johanna Stern, Sarah Moraïs, Raphael Lamed, Edward A. Bayer   +3 more
doaj   +1 more source

Enantioselective Synthesis of Lactic Acid From CO2 Using a Novel Pyruvate Decarboxylase in a Scalable Biocatalytic Cascade

Advanced Synthesis &Catalysis, Volume 368, Issue 11, 3 June 2026.
We report a scalable biocatalytic cascade that converts CO2 and acetaldehyde to pyruvate via a newly characterized pyruvate decarboxylase, followed by stereoselective reduction to lactic acid. The system enables fully switchable enantioselectivity using either L‐ or D‐lactate dehydrogenases.
Silvia Fruncillo, Daan M. van Vliet, Jurgen J. Mateman, Dirk C. van Seijst, Jan Stoutjesdijk, Jason van Rooyen, Akash Pandya, James Galman, Annette Alcasabas, Tom A. Ewing   +9 more
wiley   +1 more source

The Multienzyme Complex Nature of Dehydroepiandrosterone Sulfate Biosynthesis

International Journal of Molecular Sciences
Dehydroepiandrosterone (DHEA), a precursor of steroid sex hormones, is synthesized by steroid 17-alpha-hydroxylase/17,20-lyase (CYP17A1) with the participation of microsomal cytochrome b5 (CYB5A) and cytochrome P450 reductase (CPR), followed by sulfation by two cytosolic sulfotransferases, SULT1E1 and SULT2A1, for storage and transport to tissues in ...
Anastasiya Tumilovich, Evgeniy Yablokov, Yuri Mezentsev, Pavel Ershov, Viktoriia Basina, Oksana Gnedenko, Leonid Kaluzhskiy, Tatsiana Tsybruk, Irina Grabovec, Maryia Kisel, Polina Shabunya, Natalia Soloveva, Nikita Vavilov, Andrei Gilep, Alexis Ivanov   +14 more
openaire   +2 more sources

Transcriptomic Analysis in the Liver of Two Rabbit Lines Divergently Selected for Intramuscular Fat Content

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT The intramuscular fat (IMF) content is an important indicator of meat quality, affecting the sensory properties of meat. IMF is a complex trait with polygenic nature. This research aimed to identify differentially expressed (DE) genes and key transcription factors (TFs) associated with IMF deposition in the liver of two rabbit lines ...
Jesús Valdés‐Hernández, Agostina Zubiri‐Gaitán, Marina Martínez‐Álvaro, Agustín Blasco, Pilar Hernández   +4 more
wiley   +1 more source

Deconstruction by C. thermocellum —from microbe mediated to dynamic redistribution of cellulosomes

Life Science Alliance
By combining super-resolution imaging and machine learning to study the dynamics of biomass deconstruction by C. thermocellum , we show that this deconstruction goes from a microbe-mediated strategy to a dynamic redistribution of cellulosomes during ...
John M Yarbrough, Neal N Hengge, Qi Xu, Samantha J Ziegler, Daehwan Chung, Shu Huang, Sarah Moraïs, Itzhak Mizrahi, Edward A Bayer, Yannick J Bomble   +9 more
doaj   +1 more source