Results 81 to 90 of about 12,911 (210)

Production and characterization of murine models of classic and intermediate maple syrup urine disease [PDF]

, 2006
Background Maple Syrup Urine Disease (MSUD) is an inborn error of metabolism caused by a deficiency of branched-chain keto acid dehydrogenase. MSUD has several clinical phenotypes depending on the degree of enzyme deficiency.
Gregg E Homanics, Kristen Skvorak, Carolyn Ferguson, Simon Watkins, Harbhajan S Paul, D Chuang, L Marshall, S Yeaman, M Yoshino, H Paul, R Paxton, F Peinemann, DH Morton, R Cox, DJ Danner, BS Khatra, A Suryawan, A Bodner-Leidecker, JC Netter, U Wendel, KA Strauss, PA Harper, B Zhang, JD Baird, J-Y Wu, SL Mansour, V Tybulewicz, A Nagy, GE Homanics, M Gossen, RL Brinster, RD Palmiter, M Kozak, GE Homanics, SM Hutson, H Paul, GW Snedecor, A Harper, A Kistner, A Mattevi, JE Knapp, DT Chuang, L Wang, S Mochizuki, GM Mueller, H Koyata, G Ambrosino, M Muraca, JH Fair, J Chuang, J Li   +50 more
core   +1 more source

Electroenzymatic Cascades for Nitrogen Upgrading: Beyond Ammonia Towards Value‐Added Nitrogen Chemicals

ChemCatChem, Volume 18, Issue 7, 14 April 2026.
This review maps how electroenzymatic cascades that couple nitrogen‐cycle enzymes with C─N bond forming auxilary enzymes, powered by direct electron transfer (DET) or mediated electron transfer (MET), can upgrade N2 and waste nitrogen streams into value‐added amines, amides, amino acids, and other nitrogen‐based chemicals.
Rohit G. Jadhav, Vamshi Krishna Kamaja, Wassim El Housseini, Monica Brachi, Shelley D. Minteer   +4 more
wiley   +1 more source

Oxide Interface of Gallium‐Based Liquid Metals: Beneficial Bridge or Hidden Risk?

ChemistryEurope, Volume 4, Issue 4, April 2026.
Discussion on oxide interfaces in gallium‐based liquid metals have concentrated on their properties, behaviors, and related applications. However, the molecular mechanisms underlying effects, as well as the differences between the presence and absence of the oxide layer, have been less thoroughly discussed.
Yi Fan, Shuai Wang, Xu Hou
wiley   +1 more source

Structure and function of eukaryotic fatty acid synthases [PDF]

, 2017
In all organisms, fatty acid synthesis is achieved in variations of a common cyclic reaction pathway by stepwise, iterative elongation of precursors with two-carbon extender units.
Ban, Nenad, Boehringer, Daniel, Leibundgut, Marc, Maier, Timm   +3 more
core  

EnzRetro: Enzymatic Retrosynthetic Planning With Site‐Specific Reaction Edits Based on Sequence Generative Architecture

Exploration, Volume 6, Issue 2, April 2026.
EnzRetro bridges retrosynthesis planning and enzymatic engineering through site‐specific reaction edits. This end‐to‐end framework integrates pathway synthesis and enzyme identification into a unified process, achieving superior accuracy and enabling the efficient reconstruction of diverse biosynthetic pathways.
Yahui Cao, Haoshu Chen, Tao Zhang, Xin Zhao, Bingzhi Li, Xiangrui Zheng   +5 more
wiley   +1 more source

Respiratory electron transfer pathways in plant mitochondria [PDF]

, 2014
The respiratory electron transport chain (ETC) couples electron transfer from organic substrates onto molecular oxygen with proton translocation across the inner mitochondrial membrane.
Braun, Hans-Peter, Schertl, Peter
core   +4 more sources

Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
The potential of Leishmania‐derived extracellular vesicles (EVs) as a vaccine platform was investigated, emphasizing an affordable, GMP‐compliant production and purification method. Immunization with EV vaccines, either unadjuvanted or combined with α‐galactosylceramide (αGC), induced robust humoral and cellular immune responses, conferring protection ...
Ismail Cem Yilmaz, Ibrahim Tokmak, Muzaffer Yildirim, Tugce Canavar Yildirim, Elif Sena Ozkoc, Irem Evcili, Emre Mert Ipekoglu, İhsan Cihan Ayanoglu, Emre Dunuroglu, Dicle Caliskan, Harun Onler, Zeynep Arzum, Ceren Ulker, Olcay Mert, Ridvan Orkut, Ibrahim Oguzhan Tarman, Ulku Guler, Bekir Salih, Volkan Yazar, Gokcen Ozgun, Serap Birincioglu, Ahmet Ozbilgin, Bilgi Gungor, Ihsan Gursel, Mayda Gursel   +24 more
wiley   +1 more source

Mechanism of subunit interaction at ketosynthase-dehydratase junctions in trans-AT polyketide synthases [PDF]

, 2018
Modular polyketide synthases (PKSs) produce numerous structurally complex natural products with diverse applications in medicine and agriculture. They typically consist of several multienzyme subunits that utilize structurally-defined docking domains ...
A Keatinge-Clay, AG Palmer III., Andrew S Barrow, AS Worthington, AS Worthington, AT Keatinge-Clay, AT Keatinge-Clay, BG Pierce, C Hertweck, CD Richter, Daniel Griffiths, DT Wagner, DT Wagner, E Lescop, EJN Helfrich, FH Schumann, GM Pavlović-Lažetić, Gregory L Challis, J Bellay, J Dorival, J Kuo, J Nilsson, J Yang, J Zeng, JG Lees, JL Meier, John E Moses, Józef R Lewandowski, KJ Weissman, L Gitlin, L Katz, L Manzi, L Song, L Whitmore, LJ McGuffin, Lucio Manzi, MA Fischbach, MA Larkin, Matthew Jenner, MP Williamson, MR Jensen, Neil J Oldham, Panward Prasongpholchai, PE Wright, RS Gokhale, RW Broadhurst, S Kapur, S Kosol, S Vucetic, Simone Kosol, SR Eddy, TJ Buchholz, V Neduva, VB Chen, VN Uversky, WF Vranken, YS Lin, Z Dosztányi, Z Dosztányi   +58 more
core   +3 more sources

Incomplete Wood-Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi. [PDF]

, 2014
The acetyl-CoA "Wood-Ljungdahl" pathway couples the folate-mediated one-carbon (C1) metabolism to either CO2 reduction or acetate oxidation via acetyl-CoA.
Alvarez-Cohen, Lisa, Bill, Markus, Brisson, Vanessa L, Conrad, Mark E, Feng, Xueyang, Men, Yujie, Tang, Yinjie J, Yi, Shan, Zhuang, Wei-Qin   +8 more
core   +1 more source

Hsp90 Promotes Gastric Cancer Cell Metastasis and Stemness by Regulating the Regional Distribution of Glycolysis‐Related Metabolic Enzymes in the Cytoplasm

Advanced Science
Heat‐shock protein 90 (Hsp90) plays a crucial role in tumorigenesis and tumor progression; however, its mechanism of action in gastric cancer (GC) remains unclear. Here, the role of Hsp90 in GC metabolism is the focus of this research. High expression of
Shiya Liu, Gaigai Shen, Xuanyu Zhou, Lixin Sun, Long Yu, Yuanting Cao, Xiong Shu, Yuliang Ran   +7 more
doaj   +1 more source