Results 201 to 210 of about 17,949 (246)
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Multifactorial inheritance of non‐syndromic macrocephaly
Clinical Genetics, 1996Objective: To reevaluate previous claims that non‐syndromic macrocephaly is usually inherited as an autosomal dominant trait. Design: Head size was measured in the parents and sibs of children with non‐syndromic macrocephaly. Outcome measures: If autosomal dominant inheritance is involved, the frequency distribution should be bimodal.
L, Arbour +3 more
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Multifactorial inheritance in type 1 diabetes
Trends in Genetics, 1995To date, twelve separate chromosome regions have been implicated in the development of human type 1 (insulin-dependent) diabetes mellitus. The major disease locus, IDDM1 in the major histocompatibility complex(MHC) on chromosome 6p21, accounts for about 35% of the observed familial clustering and its contribution to disease susceptibility is likely to ...
H J, Cordell, J A, Todd
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Multifactorial Inheritance and Heritability in Pharmacogenetics
1978Unimodal Gaussian distribution curves are usually observed when drug metabolism is studied in human subjects. Greater similarity of identical twins as compared with fraternal twins suggests genetic influences on the metabolism of many drugs. Lack of distinct segregation into monogenically defined classes and the high heritability observed in twin data ...
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Major gene and multifactorial inheritance of mandibular prognathism
American Journal of Medical Genetics Part A, 2007AbstractMandibular prognathism typically shows familial aggregation. Various genetic models have been described and it is assumed to be a multifactorial and polygenic trait, with a threshold for expression. Our goal was to examine specific genetic models of the familial transmission of this trait. The study sample comprised of 2,562 individuals from 55
Ricardo Machado, Cruz +5 more
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Polygenic and multifactorial inheritance
1999Abstract In previous chapters, attention has focused on risk calculation in single gene disorders. In this chapter, we shall consider how to approach the difficult task of estimating risks for the large number of human characteristics and diseases which clearly have an underlying genetic component but which do not conform to any obvious ...
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The Land Between Mendelian and Multifactorial Inheritance
Science, 2001Bardet-Biedl syndrome (BBS) is a heterogeneous multigenic disease that turns out to have an unusual form of inheritance ( Katsanis et al .). As Burghes et al . explain in their Perspective, the disease phenotype only appears if one copy of a modifier gene at one of five loci is mutated in addition to the two copies of ...
Arthur H. M. Burghes +2 more
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Polygenic and Multifactorial Inheritance
2006Abstract In previous chapters, attention has focused on risk calculation in single-gene disorders. In this chapter, we shall consider how to approach the difficult task of estimating risks for the large number of human characteristics and diseases that clearly have an underlying genetic component but that do not conform to any obvious ...
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Multifactorial Inheritance of White Facial Markings in the Arabian Horse
Journal of Heredity, 1989The hypothesis was tested that white facial markings in the Arabian horse show multifactorial inheritance. The hypothesis assumes that (1) alleles at different loci acting in a cumulative manner influence the variation in white facial markings, (2) the amount of whiteness is correlated with the number of genes, and (3) interacting nongenetic factors ...
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Complex Disorders and Polygenic and Multifactorial Inheritance
This chapter examines polygenic and multifactorial inheritance, differentiating them from Mendelian inheritance patterns. It explains how multiple genes and environmental factors influence complex traits, contributing to disorders such as schizophrenia, hypertension, and stroke.Nirmal Vadgama +3 more
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