Results 61 to 70 of about 2,391 (172)

Multifocal Electroretinogram in normal subjects [PDF]

Sohag Medical Journal, 2017
Background: Multifocal electroretinogram (mfERG) is a device for recording the physiological response of multiple retinal areas in short time. Using this technique enables us to detect the spatial extent and severity of the retinal damage. Objectives: In this study,we aimed to assess the topographic properties of mfERG in normal subjects to use it as a
Ahmad Abd Allah, Hatem Ammar, Kariman Tamam, Yoshiaki Shimada   +3 more
openaire   +1 more source

New insights into applications of base editor in hereditary disorders

Interdisciplinary Medicine, Volume 3, Issue 6, November 2025.
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai, Linhui Zhang, Liqing Li, Yue Liu, Canbin Lv, Yan Shi, Jianyuan Zhao, Dingwei Ye, Yuanyuan Qu   +8 more
wiley   +1 more source

Multifocal electroretinogram evaluation of different optical coherence tomography patterns of diabetic macular edema

Journal of the Egyptian Ophthalmological Society
Purpose To correlate macular function to morphological patterns of diabetic macular edema (DME) observed by optical coherence tomography (OCT). Patients and methods This study included 100 DME eyes and 60 control eyes.
Abdelrahman W.M. Mohamed, Yehia M. Khairat, Heba R. AttaAllah, Amr A.M. Abdelrahman   +3 more
doaj   +1 more source

Comparison of retinal function and macular structure after 27G pars plana vitrectomy with minimal heads‐up versus standard illumination in patients with idiopathic epiretinal membranes: A pilot randomized study

Acta Ophthalmologica, Volume 103, Issue 7, Page e456-e471, November 2025.
Abstract Purpose To analyse the clinical benefits of using the NGENUITY 3D Visualization System in vitreoretinal surgery with low levels of endoillumination, focusing on functional and structural retinal protection in patients with idiopathic epiretinal membranes (ERM). Design Prospective, randomized, comparative study.
Wojciech Lubiński, Tomasz Charabin, Karolina Podborączyńska‐Jodko, Maciej Mularczyk, Ewelina Lachowicz‐Gosławska   +4 more
wiley   +1 more source

Stellate Nonhereditary Idiopathic Foveomacular Retinoschisis: Cataract Surgery

Case Reports in Ophthalmological Medicine, 2022
Purpose. We present the first case described in the literature of cataract surgery in a patient with stellate nonhereditary idiopathic foveomacular retinoschisis (SNIF). Methods. In this case report, we describe the extensive workup we did on our patient,
Sofie Van der Auwera, Oscar Kallay
doaj   +1 more source

Retinal biomarkers in cognitive impairment and dementia: Structural, functional, and molecular insights

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract Cognitive impairment and dementia, including Alzheimer's disease (AD), pose a global health crisis, necessitating non‐invasive biomarkers for early detection. This review highlights the retina, an accessible extension of the central nervous system (CNS), as a window to cerebral pathology through structural, functional, and molecular ...
Yan Min, Hongyu Zhou, Zixiao Li, Yongjun Wang   +3 more
wiley   +1 more source

Macular function and morphology in acute retinal pigment epithelitis

Indian Journal of Ophthalmology, 2014
A 20-year-old man applied with vision loss in the left eye. Right eye examination was unremarkable. Best-corrected visual acuity (BCVA) in the left eye was 20/200.
Fatih C Gundogan, Oktay Diner, Ahmet Tas, Abdullah Ilhan, Umit Yolcu   +4 more
doaj   +1 more source

Multifocal Electroretinograms in X-Linked Retinoschisis

Investigative Opthalmology & Visual Science, 2003
To study local retinal cone function in patients with X-linked retinoschisis (XLRS) by multifocal ERGs (mfERGs).mfERGs were recorded from seven eyes of seven patients with XLRS (mean age +/- SD, 22.1 +/- 3.2 years; range, 18 to 25 years). Five eyes had microcystic changes in the macula and two eyes had nonspecific macular degeneration.
Chang-Hua, Piao, Mineo, Kondo, Makoto, Nakamura, Hiroko, Terasaki, Yozo, Miyake   +4 more
openaire   +2 more sources

First‐in‐human phase 1 study of KHK2455 monotherapy and in combination with mogamulizumab in patients with advanced solid tumors

Cancer, Volume 131, Issue 13, 1 July 2025.
Abstract Background Indoleamine 2,3‐dioxygenase 1 (IDO1) is a heme‐containing enzyme that degrades tryptophan (Trp) to kynurenine (Kyn), which suppresses effector T cells and reduces antitumor activity. KHK2455 is a long‐acting selective IDO1 inhibitor that blocks the heme component of the IDO holoenzyme.
Timothy A. Yap, Olivier Rixe, Capucine Baldini, Ursa Brown‐Glaberman, Sergey Efuni, David S. Hong, Christophe Massard, Jameel Muzaffar, Andreea Varga, Emrullah Yilmaz, Yuta Ikawa, Lisa H. Shiue, Yi Liu, Matthew W. Hruska, Henry Zhao, Akihiro Tokunaga, Solmaz Sahebjam   +16 more
wiley   +1 more source

Outer Retinal Microstructure in a Case of Acute Idiopathic Blind Spot Enlargement Syndrome

Case Reports in Ophthalmology, 2011
Purpose: To present a patient with acute idiopathic blind spot enlargement syndrome who had abnormal changes in the outer retinal microstructure limited to areas with reduced responses on multifocal electroretinograms as well as to the area involving a ...
Michitaka Sugahara, Kei Shinoda, Soiti Celso Matsumoto, Shingo Satofuka, Gen Hanazono, Yutaka Imamura, Atsushi Mizota   +6 more
doaj   +1 more source