Results 41 to 50 of about 2,719 (152)

Establishment of a novel alloxan‐induced rabbit model exhibiting unique diabetic retinal neuropathy features assessed via ERG + VEP

Animal Models and Experimental Medicine, Volume 8, Issue 9, Page 1552-1566, September 2025.
Study workflow. Neuroretinal changes were observed in alloxan‐induced diabetic rabbits, while the retinal vasculature remained unaffected, indicating the successful establishment of a diabetic neuroretinal model. Abstract Background Diabetic retinal neuropathy (DRN) leads to significant visual impairment; however, no existing animal model fully ...
Xinlu Li, Xiaojing Dong, Defei Feng, Han Hu, Bai Li, Zhongjian Liu, Wei He, Chenchen Huang, Zhizhou Shi, Yan Mei   +9 more
wiley   +1 more source

Multifocal Electroretinography in Assessment Of Diseases Of Posterior Pole Of Retina

, 2013
Multifocal electroretinography (mfERG) based on the m-sequence stimulation technique which allows quick simultaneous recording of many local electroretinograms from the posterior pole.
Geeta B. Nair, JagdeepKaur S. Dani, Mitesh M. Sinh, Archana H. Patel, Anju B. Mehta   +4 more
core   +1 more source

First‐in‐human phase 1 study of KHK2455 monotherapy and in combination with mogamulizumab in patients with advanced solid tumors

Cancer, Volume 131, Issue 13, 1 July 2025.
Abstract Background Indoleamine 2,3‐dioxygenase 1 (IDO1) is a heme‐containing enzyme that degrades tryptophan (Trp) to kynurenine (Kyn), which suppresses effector T cells and reduces antitumor activity. KHK2455 is a long‐acting selective IDO1 inhibitor that blocks the heme component of the IDO holoenzyme.
Timothy A. Yap, Olivier Rixe, Capucine Baldini, Ursa Brown‐Glaberman, Sergey Efuni, David S. Hong, Christophe Massard, Jameel Muzaffar, Andreea Varga, Emrullah Yilmaz, Yuta Ikawa, Lisa H. Shiue, Yi Liu, Matthew W. Hruska, Henry Zhao, Akihiro Tokunaga, Solmaz Sahebjam   +16 more
wiley   +1 more source

Sensitivity and Specificity of Multifocal Electroretinography in Detecting Chloroquine and Hydroxychloroquine Retinal Toxicity

, 2015
To calculate the sensitivity and specificity of multifocal electroretinography (mfERG) in detection of chloroquine and hydroxychloroquine retinal toxicity, 120 eyes of 63 patients were evaluated using the currently recommended diagnostic tests.
Ahmadi Pirshahid, Sina
core   +2 more sources

Consensus guidelines for nomenclature of companion animal inherited retinal disorders

Veterinary Ophthalmology, Volume 28, Issue 3, Page 663-667, May 2025.
Abstract Companion animals, namely dogs, cats, and horses, can be affected with many forms of hereditary retinal disease. The number of such diseases characterized in the last decade has increased substantially, and nomenclature is nonstandardized, heterogenous, and confusing.
Freya M. Mowat, Simone Iwabe, Gustavo D. Aguirre, Simon M. Petersen‐Jones   +3 more
wiley   +1 more source

Multifocal Electroretinography in Retinitis Pigmentosa With Non-recordable Full-field Electroretinography

Journal of the Korean Ophthalmological Society, 2009
Purpose: To investigate the clinical potential of multifocal electroretinography (mf-ERG) for the evaluation of residual retinal function in retinitis pigmentosa (RP). Methods: From a group of 41 patients with RP examined for full-field and mf-ERGs, 24 patients were selected in whom the full-field ERGs were non-detectable. Data from the mf-ERGs of this
Sun Young Jang, Sang Hyun Lim, Young-Hoon Ohn   +2 more
openaire   +1 more source

Expanding the genetic landscape of Usher syndrome type IV caused by pathogenic ARSG variants

Clinical Genetics, Volume 107, Issue 1, Page 44-55, January 2025.
Mutations in ARSG are a very rare cause of Usher disease, assigned as “Usher type IV.” We identified 13 new subjects with mutations in ARSG, provide a clinical description of the subjects, and characterized the newly identified variants. Abstract Usher syndrome (USH) is the most common cause of deafblindness.
Miriam Bauwens, Vincent De Man, Isabelle Audo, Irina Balikova, Wadih M. Zein, Vasily Smirnov, Sebastian Held, Sascha Vermeer, Elke Loos, Julie Jacob, Ingele Casteels, Julie Désir, Fanny Depasse, Stijn Van de Sompele, Mattias Van Heetvelde, Marieke De Bruyne, Camille Andrieu, Christel Condroyer, Aline Antonio, Robert B. Hufnagel, Ana Luísa Carvalho, João Pedro Marques, Christina Zeitz, Elfride De Baere, Markus Damme   +24 more
wiley   +1 more source

The relationship between ON–OFF function and OCT structural and angiographic parameters in early diabetic retinal disease

Ophthalmic and Physiological Optics, Volume 45, Issue 1, Page 77-88, January 2025.
Abstract Purpose This study measured associations between ON and OFF functional indicators and structural optical coherence tomography (OCT) and OCT angiography (OCTA) markers in diabetic retinal disease. Methods Fifty‐four participants with type 1 or type 2 diabetes (mean age = 34.1 years; range 18–60) and 48 age‐matched controls (mean age = 35.4 ...
Vanessa T. S. Tang, Robert C. A. Symons, Spiros Fourlanos, Daryl Guest, Allison M. McKendrick   +4 more
wiley   +1 more source

Presumed X‐Linked Retinoschisis in a 3‐Month‐Old Baby Girl: A Case Report

Case Reports in Ophthalmological Medicine, Volume 2025, Issue 1, 2025.
Purpose The purpose of the study is to report a 3‐month‐old Iranian baby girl presenting with bilateral macular and peripheral retinoschisis with a probable diagnosis of X‐linked retinoschisis (XLRS). Methods The baby underwent an ophthalmic examination under general anesthesia revealing bilateral vitreous hemorrhage, spoke‐wheel pattern radiating from
Hanieh Fakhredin, Esmaeil Asadi Khameneh, Shahin Faghihi, Mohammadreza Mehrabi Bahar, Fatemeh Bazvand, Hannah Wesley   +5 more
wiley   +1 more source

Bilateral Foveal Cysts in Mucopolysaccharidosis Type I (Hurler Syndrome): Response to Acetazolamide With Insights From Multimodal Retinal Imaging and Electrophysiology

Case Reports in Ophthalmological Medicine, Volume 2025, Issue 1, 2025.
Objective The aim of this study is to report a case of bilateral foveal cysts in MPS I‐H resolving with oral acetazolamide and to highlight the diagnostic value of multimodal retinal imaging and electrophysiological testing. Introduction Hurler syndrome (mucopolysaccharidosis Type I‐H) is a lysosomal storage disorder that can cause progressive ...
Rashmi Lobo, Ahmed Al-Hinai, Aisha Al Busaidi, Stephen G. Schwartz   +3 more
wiley   +1 more source