Results 31 to 40 of about 386,727 (312)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Handheld Multifunctional Fluorescence Imager for Non-invasive Plant Phenotyping

open access: yesFrontiers in Plant Science, 2022
Fluorescence imaging has shown great potential in non-invasive plant monitoring and analysis. However, current systems have several limitations, such as bulky size, high cost, contact measurement, and lack of multifunctionality, which may hinder its ...
Ruochong Zhang   +10 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Multifunctional Reactors [PDF]

open access: yesChemical Engineering Science, 1992
Multifunctional reactors are single pieces of equipment in which, besides the reaction, other functions are carried out simultaneously. The other functions can be a heat, mass or momentum transfer operation and even another reaction. Multifunctional reactors are not new, but they have received much emphasis in research in the last decade.
openaire   +4 more sources

Cs2AgBiBr6 and related Halide double perovskite porous single crystals

open access: yesScientific Reports
The utilization of single crystals is exponentially growing in optoelectronic devices due to their exceptional benefits, including high phase purity and the absence of grain boundaries.
Maurya Sandeep Pradeepkumar   +3 more
doaj   +1 more source

Permeabilidade de concretos refratários multifuncionais Permeability of multifunctional refractory castables

open access: yesCerâmica, 2001
Concretos multifuncionais oferecem como principal vantagem a possibilidade de aplicação do material refratário através de diversas técnicas de instalação (p.e. socagem, vibração, projeção, auto-escoamento) variando-se apenas o teor de água.
M. D. M. Innocentini   +3 more
doaj   +1 more source

Hyaluronan Mediated Motility Receptor (HMMR) Encodes an Evolutionarily Conserved Homeostasis, Mitosis, and Meiosis Regulator Rather than a Hyaluronan Receptor

open access: yesCells, 2020
Hyaluronan is an extracellular matrix component that absorbs water in tissues and engages cell surface receptors, like Cluster of Differentiation 44 (CD44), to promote cellular growth and movement.
Zhengcheng He   +3 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

ZrO2 Aerogel‐Supported Pd Nanoparticles for Photothermal CO2 Reduction

open access: yesAdvanced Science
Decarbonizing chemical processes requires sustainable heat sources that can replace fossil‐derived fuels and feedstocks. In photothermal catalysis, heat is supplied by converting light directly on the catalyst surface.
David Kiwic   +3 more
doaj   +1 more source

Bioinformatics and moonlighting proteins

open access: yesFrontiers in Bioengineering and Biotechnology, 2015
Multitasking or moonlighting is the capability of some proteins to execute two or more biochemical functions. Usually, moonlighting proteins are experimentally revealed by serendipity.
Sergio eHernández   +8 more
doaj   +1 more source

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