Results 41 to 50 of about 57,955 (312)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Setting up and management of public policies multifunctional purpose. The case of Developing Countries : Capitalisation of research results on the multifunctionality of agriculture and rural areas [PDF]

, 2005
The notion of multifuncionality appeared for the first time in 1992 in the proceedings of the International Conference of the United Nations on Environment and Development.
Bonnal, Philippe, Losch, Bruno, Van Vliet, Geert   +2 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Soil multifunctionality in arid mining: Driving mechanisms and restoration strategies based on natural succession

Ecological Indicators
Ecological restoration in coal mining areas often relies mainly on artificial intervention. Restoration efficiency and long-term maintenance of soil multifunctionality remain limited due to an insufficient understanding of natural succession mechanisms ...
Xiaonan Li, Kai Zhang
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Sustainable land management enhances ecological and economic multifunctionality under ambient and future climate

Nature Communications
The currently dominant types of land management are threatening the multifunctionality of ecosystems, which is vital for human well-being. Here, we present a novel ecological-economic assessment of how multifunctionality of agroecosystems in Central ...
Friedrich Scherzinger, Martin Schädler, Thomas Reitz, Rui Yin, Harald Auge, Ines Merbach, Christiane Roscher, W Stanley Harpole, Evgenia Blagodatskaya, Julia Siebert, Marcel Ciobanu, Fabian Marder, Nico Eisenhauer, Martin Quaas   +13 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Microbial network structure, not plant and microbial community diversity, regulates multifunctionality under increased precipitation in a cold steppe

Frontiers in Microbiology
It is known that the dynamics of multiple ecosystem functions (i. e., multifunctionality) are positively associated with microbial diversity and/or biodiversity. However, how the relationship between microbial species affects ecosystem multifunctionality
Xuechen Yang, Xuechen Yang, Wenzheng Song, Xue Yang, Xue Yang, Tianxue Yang, Wenqing Bao, Chengliang Wang, Junqin Li, Shangzhi Zhong, Shangzhi Zhong, Qi Jiang, Qi Jiang, Lu-Jun Li, Wei Sun   +14 more
doaj   +1 more source

Multifunctional agriculture: The effect of non-public goods on socially optimal policies [PDF]

, 2005
We develop a general framework for multifunctional agriculture, which includes not only public goods but also rural viability as a non-public good item. We contribute to the literaure in two ways.
Lankoski, Jussi, Ollikainen, Markku
core  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source