Results 181 to 190 of about 38,467 (245)
Synthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization Inhibitors
ACS Medicinal Chemistry Letters, 2018 HIV-1 integrase multimerization inhibitors have recently been established as an effective class of antiretroviral agents due to their potent ability to inhibit viral replication.
Jacques Kessl +2 more
exaly +3 more sources
ATP13A2 Regulates Cellular α-Synuclein Multimerization, Membrane Association, and Externalization
International Journal of Molecular Sciences, 2021 ATP13A2, a late endo-/lysosomal polyamine transporter, is implicated in a variety of neurodegenerative diseases, including Parkinson’s disease and Kufor–Rakeb syndrome, an early-onset atypical form of parkinsonism.
Veerle Baekelandt +2 more
exaly +2 more sources
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Metabolism: Clinical and Experimental, 2023
BACKGROUND The regulatory mechanisms involved in mitochondrial quality control (MQC) dysfunction during septic cardiomyopathy (SCM) remain incompletely characterized.
Hao Zhou +6 more
semanticscholar +1 more source
BACKGROUND The regulatory mechanisms involved in mitochondrial quality control (MQC) dysfunction during septic cardiomyopathy (SCM) remain incompletely characterized.
Hao Zhou +6 more
semanticscholar +1 more source
Multimerization and Retention of the Scavenger Receptor SR-B1 in the Plasma Membrane
Developmental Cell, 2019 Scavenger receptor B1 (SR-B1), the main receptor for high-density lipoprotein (HDL), is key in preventing atherosclerosis. It removes cholesterol from HDL, returning the lipid-poor lipoprotein to the circulation. To study the mechanisms controlling SR-B1
William Trimble +2 more
exaly +2 more sources
BTB domains: A structural view of evolution, multimerization, and protein–protein interactions
Bioessays, 2022Broad‐complex, Tramtrack, and Bric‐à‐brac/poxvirus and zinc finger (BTB/POZ) is a conserved domain found in many eukaryotic proteins with diverse cellular functions. Recent studies revealed its importance in multiple developmental processes as well as in
A. Bonchuk, K. Balagurov, P. Georgiev
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Trends in Endocrinology & Metabolism, 1994
Cytokines are pleiotropic regulators that control proliferation, differentiation, and other cellular functions. They play a pivotal role in the immune and hematopoietic systems, and subsets of cytokines often exhibit similar biologic activities in common target cells. Recent cloning of genes for the cytokine receptors has provided new insights into the
T, Kitamura, T, Ogorochi, A, Miyajima
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Cytokines are pleiotropic regulators that control proliferation, differentiation, and other cellular functions. They play a pivotal role in the immune and hematopoietic systems, and subsets of cytokines often exhibit similar biologic activities in common target cells. Recent cloning of genes for the cytokine receptors has provided new insights into the
T, Kitamura, T, Ogorochi, A, Miyajima
openaire +2 more sources
Development and validation of a cell-based assay system to assess human immunodeficiency virus type 1 integrase multimerization [PDF]
Journal of Virological Methods, 2016 Multimerization of HIV-1 integrase (IN) subunits is required for the concerted integration of HIV-1 proviral DNA into the host genome. Thus, the disruption of IN multimerization represents a new avenue for intervening HIV-1 infection.
Hiroaki Mitsuya, Amber Moore
exaly +2 more sources
Probability distributions for multimeric systems
Journal of Mathematical Biology, 2015We propose a fast and accurate method of obtaining the equilibrium mono-modal joint probability distributions for multimeric systems. The method necessitates only two assumptions: the copy number of all species of molecule may be treated as continuous; and, the probability density functions (pdf) are well-approximated by multivariate skew normal ...
Albert, Jaroslav, Rooman, Marianne
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