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Recent Advances in Multimodal Analgesia

Anesthesiology Clinics, 2012
Greater understanding of the pathophysiology and mechanism of acute pain has led to advances in pharmacologic therapy. Understanding the principles of multimodal therapy along with surgical-specific protocols leads to improved outcome in patients. However, further large-scale randomized trials need to be performed to further establish and demonstrate ...
Adam, Young, Asokumar, Buvanendran
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Multimodal analgesia in orthognathic surgery

Journal of Oral and Maxillofacial Anesthesia, 2022
Orthognathic surgery, as part of maxillofacial surgery, involves the correction of dentofacial deformities for both functional (occlusion, speech and sleep disturbances) and aesthetic reasons. Deformities of this kind affect between 5–10% of the general population. The underlying causes are not clear, though genetic, environmental and embryonic factors
Molins-Ballabriga, Gloria   +3 more
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Multimodal Analgesia for Hip Arthroplasty

Orthopedic Clinics of North America, 2009
Multimodal analgesia incorporates the use of analgesic adjuncts with different mechanisms of action to enhance postoperative pain management. Acetaminophen, anti-inflammatories, and gabapentinoids provide effective analgesia while reducing opioid requirements and opioid-related side effects.
Raymond, Tang   +3 more
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Multimodal therapy in perioperative analgesia

Best Practice & Research Clinical Anaesthesiology, 2014
This article reviews the current evidence for multimodal analgesic options for common surgical procedures. As perioperative physicians, we have come a long way from using only opioids for postoperative pain to combinations of acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), selective Cyclo-oxygenase (COX-2) inhibitors, local anesthetics, N-
Karina, Gritsenko   +4 more
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Multimodal and Balanced Analgesia

Veterinary Research Communications, 2007
Corletto, F., 2007. Multimodal and balanced analgesia. Veterinary Research Communications, 31(Suppl.
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Postoperative Multimodal Analgesia in Cardiac Surgery

Critical Care Clinics, 2020
Multimodal pain management of cardiac surgical patients is a paradigm shift in postoperative care. This promising approach features complementary medications and techniques that spare opioids and improves symptomatic and functional recovery. Although the specific elements remain to be defined, the collaboration of the health care team and patient and ...
Linda F, Barr   +4 more
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Multimodal analgesia in children

European Journal of Anaesthesiology, 2010
Acute and chronic pain management in children is increasingly characterized by either a multimodal or a preventive analgesia approach, in which smaller doses of opioid and nonopioid analgesics, such as nonsteroidal anti-inflammatory drugs, local anaesthetics, N-methyl-D-aspartate antagonists, alpha(2)-adrenergic agonists, and voltage-gated calcium ...
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Multimodal Analgesia for Total Joint Arthroplasty

Orthopedics, 2015
Optimal perioperative pain control for total joint arthroplasty remains a challenge. Whereas traditional regimens have relied heavily on opioids, newer multimodal pathways are increasingly gaining popularity as safer and more effective alternatives.
Mohamad J, Halawi   +2 more
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Clinical application of perioperative multimodal analgesia

Current Opinion in Supportive & Palliative Care, 2017
Purpose of review The experience of intense postoperative pain remains a significant problem in perioperative medicine. The mainstay of postoperative analgetic therapy is the combination of nonopioid agents (e.g. paracetamol and NSAIDs) with strong opioids (e.g. morphine) according to the WHO analgesic ladder.
Bruhn, J.   +2 more
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Multimodal analgesia for postoperative pain control

Journal of Clinical Anesthesia, 2001
Pain is one of the main postoperative adverse outcomes. Single analgesics, either opioid or nonsteroidal antiinflammatory drugs (NSAIDs), are not able to provide effective pain relief without side effects such as nausea, vomiting, sedation, or bleeding.
F, Jin, F, Chung
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