Results 81 to 90 of about 228,949 (361)

The need to achive a multimodal therapeutical approach in glioblastoma [PDF]

Romanian Journal of Neurology, 2011
It is well-known that of all the brain gliomas the glioblastoma multiforme has always caused serious difficulties regarding its therapeutic solution by means of different methods. Glioblastoma multiforme is the most frequent primary brain tumor in adults.
Razvan Ion Radulescu
doaj   +1 more source

Avoidant symptoms in PTSD predict fear circuit activation during multimodal fear extinction [PDF]

, 2013
Convergent evidence suggests that individuals with posttraumatic stress disorder (PTSD) exhibit exaggerated avoidance behaviors as well as abnormalities in Pavlonian fear conditioning.
Israel eLiberzon, Israel eLiberzon, Rebecca Kaufman Sripada, Rebecca Kaufman Sripada, Sarah N Garfinkel   +4 more
core   +2 more sources

Acoustic Measures Capture Speech Dysfunction in Spinocerebellar Ataxia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxias (SCA) are hereditary cerebellar degenerative disorders with a common feature of dysarthria, involving impaired phonatory and articulatory control of speech, thereby affecting social communication. In this study, we investigated whether acoustic measures could objectively measure speech dysfunction and identify
Zena Fadel, Charlotte Hennessey, Hannah Lee, Pia Parekh, Sheng‐Han Kuo, Ami Kumar   +5 more
wiley   +1 more source

Exceptional long-term survival in an adult with advanced classic biphasic pulmonary blastoma: a case report and literature review

Frontiers in Oncology
BackgroundPulmonary blastoma (PB) is an exceedingly rare and aggressive primary lung malignancy. Classic biphasic pulmonary blastoma (CBPB), a subtype, is associated with a historically poor prognosis, particularly in advanced stages.
Jun Li, Si Chen, Qiliang Liu, Ming Li
doaj   +1 more source

Lack of evidence does not justify neglect. how can we address unmet medical needs in calciphylaxis [PDF]

, 2016
Calcific uraemic arteriolopathy (CUA), or calciphylaxis, is a rare disease predominantly occurring in comorbidity with dialysis. Due to the very low frequency of CUA, prospective studies on its management are lacking and even anecdotal reports on ...
Brandenburg, Vincent Matthias, Cozzolino, Mario, ERA-EDTA Working Group on CKD-MBD, EUCALNET, Evenepoel, Pieter, Floege, Jürgen, Goldsmith, David, Kramann, Rafael, Massy, Ziad, Mazzaferro, Sandro, Schurgers, Leon J., Sinha, Smeeta, Torregrosa, Vicens, Ureña-Torres, Pablo, Vervloet, Marc   +14 more
core   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Case Report: Negative pressure wound therapy with instillation and dwell time as adjuvant therapy for limb salvage in a complicated necrotizing fasciitis on ischemic diabetic foot

Frontiers in Surgery
BackgroundNecrotizing fasciitis superimposed on ischemic diabetic foot ulcers represents a complex and limb-threatening condition, especially in patients with multiple comorbidities such as end-stage renal disease, peripheral arterial occlusive disease ...
Shiuan-Fu Chen, Chang-Cheng Chang, Chang-Cheng Chang, Chang-Cheng Chang, Chang-Cheng Chang   +4 more
doaj   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Prospective, open, multi-centre phase I/II trial to assess safety and efficacy of neoadjuvant radiochemotherapy with docetaxel and oxaliplatin in patients with adenocarcinoma of the oesophagogastric junction [PDF]

, 2013
Background: This phase I/II-trial assessed the dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) of neoadjuvant radiochemotherapy (RCT) with docetaxel and oxaliplatin in patients with locally advanced adenocarcinoma of the oesophagogastric ...
Arnold, Dirk, Brenner, Baruch, Galle, Peter R., Gockel, Ines, Klautke, Gunther, Lang, Hauke, Möhler, Markus, Roessler, Hans-Peter, Rödel, Claus, Schimanski, Carl Christoph, Schmidberger, Heinz, Thomaidis, Thomas, Trarbach, Tanja   +12 more
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source