Results 71 to 80 of about 135,728 (298)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Epigenetic regulation of histone modifications in glioblastoma: recent advances and therapeutic insights

Biomarker Research
Glioblastoma (GBM) is the most common primary malignant brain tumor, characterized by its aggressive behavior, limited treatment options, and poor prognosis. Despite advances in surgery, radiotherapy, and chemotherapy, the median survival of GBM patients
Li Zhang, Yang Yang, Yanchu Li, Chenyu Wang, Chenbin Bian, Hongbin Wang, Feng Wang   +6 more
doaj   +1 more source

The multimodal EchoBorg: not as smart as it looks

Journal on Multimodal User Interfaces, 2022
AbstractIn this paper we present a Multimodal Echoborg interface to explore the effect of different embodiments of an Embodied Conversational Agent (ECA) in an interaction. We compared an interaction where the ECA was embodied as a virtual human (VH) with one where it was embodied as an Echoborg, i.e, a person whose actions are covertly controlled by a
Sara Falcone, Jan Kolkmeier, Merijn Bruijnes, Dirk Heylen   +3 more
openaire   +5 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Histologic Sequelae of Apical Hypertrophic Cardiomyopathy: Dystrophic Calcification

Clinical Medicine Insights: Cardiology, 2017
We present cardiac computed tomography (CT) findings demonstrating apical hypertrophic cardiomyopathy with dystrophic calcification of the left ventricular apex.
Shahryar G Saba, John N Makaryus, Navid Rahmani, Ram Jadonath   +3 more
doaj   +1 more source

Multimodality of rich clusters from the SDSS DR8 within the supercluster-void network

, 2012
We study the relations between the multimodality of galaxy clusters drawn from the SDSS DR8 and the environment where they reside. As cluster environment we consider the global luminosity density field, supercluster membership, and supercluster ...
A. Ahvensalmi, Aihara, Andrade-Santos, Araya-Melo, Bardelli, Belsole, Bird, Blanton, Blanton, Boschin, Bourdin, Burgett, Clarke, de Lapparent, E. Saar, E. Tago, E. Tempel, Einasto, Einasto, Einasto, Einasto, Einasto, Einasto, Einasto, Einasto, Einasto, Einasto, Einasto, Einasto, Einasto, Einasto, Einasto, Einasto, Espino-Briones, Fakhouri, Flin, Fraley, Gastaldello, Hahn, Haines, Hoffman, Hou, Huchra, Ihaka, J. Einasto, J. Vennik, Jeeson-Daniel, Jõeveer, Knebe, Kolokotronis, Kopylova, Kopylova, L. J. Liivamägi, Liivamägi, Loeb, Lubin, M. Einasto, M. Gramann, Markevitch, Martínez, McIntosh, Mo, Noh, Oort, Owers, P. Heinämäki, P. Nurmi, Padilla-Torres, Park, Pinkney, Plionis, Pompei, Porter, Power, Pratt, Ragone-Figueroa, Richstone, Rose, Saar, Sahni, Schirmer, Shandarin, Sheth, Skibba, Small, Smith, Solanes, Suhhonenko, Tago, Tago, Tempel, Tempel, Tempel, Turner, V. J. Martínez, Wang, White, Wolf, Zeldovich   +98 more
core   +1 more source

Multimodal Transformer for Unaligned Multimodal Language Sequences [PDF]

Proceedings of the 57th Annual Meeting of the Association for Computational Linguistics, 2019
Human language is often multimodal, which comprehends a mixture of natural language, facial gestures, and acoustic behaviors. However, two major challenges in modeling such multimodal human language time-series data exist: 1) inherent data non-alignment due to variable sampling rates for the sequences from each modality; and 2) long-range dependencies ...
Yao-Hung Hubert Tsai, Shaojie Bai, Paul Pu Liang, J. Zico Kolter, Louis-Philippe Morency, Ruslan Salakhutdinov   +5 more
openaire   +3 more sources

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Multimodality in galaxy clusters from SDSS DR8: substructure and velocity distribution

, 2012
We search for the presence of substructure, a non-Gaussian, asymmetrical velocity distribution of galaxies, and large peculiar velocities of the main galaxies in galaxy clusters with at least 50 member galaxies, drawn from the SDSS DR8.
A. Ahvensalmi, Aguerri, Aihara, Andrade-Santos, Anscombe, Araya-Melo, Barrena, Belsole, Berlind, Berrier, Bird, Biviano, Blanton, Blanton, Blanton, Boschin, Boschin, Burgett, Böhringer, Coziol, de Lapparent, Donnelly, Dressler, Dressler, Durret, D’Agostino, E. Saar, E. Tago, E. Tempel, Einasto, Einasto, Einasto, Einasto, Einasto, Einasto, Fakhouri, Flin, Fraley, Gal, Gastaldello, Giocoli, Gregory, Holopainen, Hou, Huchra, Huertas-Company, Hwang, Hwang, Ihaka, J. Einasto, J. Vennik, Jeeson-Daniel, Jõeveer, Knebe, Kolokotronis, L. J. Liivamägi, Loeb, M. Einasto, Malumuth, Martínez, McIntosh, Merritt, Merritt, Mo, Niemi, Oegerle, Ostriker, Owers, Owers, P. Heinämäki, P. Nurmi, Piffaretti, Pimbblet, Pinkney, Ramella, Ribeiro, Richstone, Serna, Shapiro, Skibba, Skibba, Smith, Solanes, Swinbank, Tago, Tago, Tempel, Tempel, Tempel, Thomas, Tovmassian, Turner, V. J. Martínez, van den Bosch, Vennik, West, West, White, White, White, Yang, Zeldovich   +101 more
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source