Results 201 to 210 of about 544,818 (296)

Targeted delivery of the CB2 receptor agonist JWH‐133 via VCAM‐1‐functionalised nanoparticles attenuates atherosclerosis and reveals sex‐specific therapeutic outcomes

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Atherosclerosis, a chronic inflammatory disease characterised by lipid accumulation and endothelial dysfunction, remains a leading cause of cardiovascular morbidity and mortality. While cannabinoid 2 (CB2) receptor agonists show therapeutic promise in preclinical studies, their systemic application is hindered by poor ...
Lucía Martín‐Navarro   +3 more
wiley   +1 more source

Sclerostin regulates bone morphogenetic protein (BMP) bioavailability through interactions with BMP complexes and fibrillin microfibrils

open access: yesThe FEBS Journal, EarlyView.
Sclerostin (SOST) is a multifunctional extracellular modulator of BMP and Wnt signaling. SOST binds with high affinity to fibrillin‐1 and fibrillin‐2, localizing it to fibrillin microfibrils and regulating its extracellular bioavailability. Fibrillin‐bound SOST cannot engage BMP‐7 prodomain (PD) complexes, revealing a competitive mechanism that ...
Annkatrin Correns   +11 more
wiley   +1 more source

C‐type cyclin CycC1;1 delays leaf senescence by interacting with and inhibiting MYC2 in Arabidopsis

open access: yesJournal of Integrative Plant Biology, EarlyView.
The C‐type cyclin CycC1;1 interacts with MYC2 and MED25 to block their association and RNA polymerase II recruitment, thereby repressing senescence‐associated gene expression and delaying leaf senescence in Arabidopsis. Unlike jasmonic acid‐inducible JAZ repressors, CycC1;1 operates independently of jasmonic acid signaling, representing an ...
Cai‐Yi Liao   +9 more
wiley   +1 more source

Faecal IgA but not salivary IgA is associated with canine atopic dermatitis

open access: yesJournal of Small Animal Practice, EarlyView.
Objectives To characterise immunoglobulin A (IgA) levels in the faeces and saliva of dogs with canine atopic dermatitis (CAD) and healthy breed matched controls. Materials and Methods Dogs with canine atopic dermatitis were recruited based on history, clinical examination and diagnostic testing where appropriate.
A. Campbell   +3 more
wiley   +1 more source

A Reconfigurable Electro-Optic Photonic Integrated Circuit Architecture. [PDF]

open access: yesMicromachines (Basel)
Lourenço P   +3 more
europepmc   +1 more source

Unexpected Suppression of Tomato Fruit Cuticle Formation by Overexpression of a Key Cutin Biosynthetic Enzyme

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Fruit cuticles regulate the diffusion of water, gases and solutes, functioning as essential protective interfaces against environmental and biotic stresses. Engineering cuticle structure and mechanics therefore represents a promising strategy for improving fruit quality and resilience.
Gulab Chand Arya   +5 more
wiley   +1 more source

Gasohol quality control for real time applications by means of a multimode interference fiber sensor. [PDF]

open access: yesSensors (Basel), 2014
Rodríguez AJ   +5 more
europepmc   +1 more source

Pinus‐derived membrane vesicles disrupt pathogenic metabolism in fungi

open access: yesPlant Biology, EarlyView.
Needle‐derived vesicles from pine trees impair fungal metabolism and growth, offering a sustainable strategy to control pine pitch canker disease. Abstract Much of what we know about the biological impacts of vesicles (MVs) is derived from Arabidopsis thaliana.
S. Kunene   +3 more
wiley   +1 more source

LGBT+ People in France and Mental Health: Changing the Boundaries

open access: yesPerspectives on Sexual and Reproductive Health, EarlyView.
ABSTRACT Introduction Studies documenting the health of sexual and gender minorities have mostly relied on practices to define minorities and have failed to examine associations between sexual and gender minorities. Methods Based on the CSF2023, a national population‐based survey on sexuality and sexual health in France, we analyze (i) the ...
Elise Marsicano   +3 more
wiley   +1 more source

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