Results 91 to 100 of about 13,046 (262)

Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels [PDF]

, 2018
Drugs do not act solely by canonical ligand–receptor binding interactions. Amphiphilic drugs partition into membranes, thereby perturbing bulk lipid bilayer properties and possibly altering the function of membrane proteins.
Aldrich, Richard W., Andersen, Olaf S., Dockendorff, Chris, Dodge, Matthew W., Eum, Kenneth S., Gandhi, Disha M., Ingolfsson, Helgi I., Kapoor, Ruchi, Kimball, Ian H., Martin, Stephen F., Peyear, Thasin, Rusinova, Radda, Sack, Jon T.   +12 more
core   +2 more sources

Absolute Bioavailability and Absorption, Distribution, Metabolism, and Excretion of [14C]Xevinapant, a Potent, Oral, Small‐Molecule IAP Inhibitor

Clinical Pharmacology in Drug Development, Volume 15, Issue 3, March 2026.
Abstract This Phase 1, open‐label, 2‐part, single‐dose study aimed to investigate the pharmacokinetics, metabolism, and excretion of xevinapant, a small molecule inhibitor of apoptosis proteins (IAPs), in healthy male subjects. Part 1 focused on determining the mass balance recovery, pharmacokinetics, and metabolic profile of [14C]xevinapant following ...
Annick Menetrey, Valérie Nicolas‐Metral, Marie‐Claude Roubaudi‐Fraschini, Tri Tat, Yuan Zhao, Yulia Vugmeyster, Karthik Venkatakrishnan, Felix Rohdich, Holger Scheible   +8 more
wiley   +1 more source

PENGARUH SHIFT KERJA TERHADAP TINGKAT STRES KERJA PADA PERAWAT RAWAT INAP RUMAH SAKIT ORTOPEDI PROF. DR. R. SOEHARSO SURAKARTA [PDF]

, 2013
Jati Uji Sekti Widyasrini, R0209025, 2013. The Effect of Working Shift on Working Stress Levels of Inpatient Nurses at Orthopaedic Hospital Prof.Dr.R.Soeharso Surakarta.
Widyasrini, Jati Uji Sekti
core  

Gas‐Phase Dehydrogenation of Perhydro Benzyltoluene Using a Commercial Pt on Alumina Catalyst–Stability and Kinetics

Energy Technology, Volume 14, Issue 3, March 2026.
Dehydrogenation of H12‐BT is normally conducted in a multiphasic reaction whereas hydrogen release lowers the partial pressure of H12‐BT and induces H12‐BT evaporation. Due to H12‐BT evaporation major parts of the released hydrogen origin from gas phase dehydrogenation.
M. Geißelbrecht, T. Mader, S. Weigelt, P. Wasserscheid   +3 more
wiley   +1 more source

Hope and Anxiety: A Meta‐analytic Review

Journal of Clinical Psychology, Volume 82, Issue 3, Page 227-247, March 2026.
ABSTRACT As the prevalence of anxiety disorders increases, there is rising interest in factors that protect against and alleviate anxiety. One such factor is hope, or the positive expectancy of utilizing pathways and agency to accomplish one′s goals.
Angela L. Richardson, Laura J. Long, Matthew W. Gallagher   +2 more
wiley   +1 more source

20 Years of Liver Biopsies at a Single Institution—Application of a Machine Learning‐Based Approach to Pathology Database Searches

Liver International Communications, Volume 7, Issue 1, March 2026.
ABSTRACT Advances in hepatology—such as noninvasive serum biomarkers (e.g., Fibrosure since 2004), imaging techniques (e.g., MR Elastography since 2009 and FibroScan since 2013), and effective direct‐acting antivirals for the treatment of chronic hepatitis C—have likely influenced liver biopsy practices.
Nazire E. Albayrak, Brandon M. Veremis, Peizi Li, Maryam Kooshesh, Joshua Onuiri, Aiswarya Irri, Maria Isabel Fiel, Swan N. Thung, Stephen C. Ward   +8 more
wiley   +1 more source

Alfalfa‐Based Dehydrated Silage Pellet as a Source of Nutrients in Laying Hens: I. Effects on Animal Performance and Egg Quality

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
Alfalfa‐based silage pellets (ABSP) showed significant results regarding production performance, yolk colour and ω‐3 (PUFAs), as well as the ratio ω‐6/ω‐3 (p < 0.05). The ABSP group also exhibited a higher abundance of beneficial bacteria and a lower abundance of pathogenic bacteria compared to the control group (p < 0.05).
Abbas Hamim, Sylvestre Habimana, Eric Hatungimana, Georges Daube, Bernard Taminiau, Caroline Douny, Jean‐Luc Hornick, Isabelle Dufrasne   +7 more
wiley   +1 more source

The effect of environment on post surgical overall well-being and pain sensitivity in an animal model [PDF]

, 2016
With chronic post surgical pain affecting up to one third of patients undergoing surgeries and the price of treatment being astoundingly high there has been a transition in research to investigate and identify risk factors. Through identification of risk
Reddy, Archana
core   +1 more source

Unveiling the Invisible: A Case of Canine Diffuse Microscopic Pancreatic Adenocarcinoma With Normal Imaging and Gross Appearance of the Pancreas Complicated by Sterile Peritonitis and Disseminated Intravascular Coagulation

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
This case report describes an atypical presentation of diffuse microscopic pancreatic adenocarcinoma in an 11‐year‐old male neutered Shetland Sheepdog, which was not detectable on advanced diagnostic imaging or during exploratory laparotomy. Despite the absence of visible pancreatic abnormalities, histopathology confirmed malignant infiltration ...
Hiu Man Chan, Marie‐Laure Théron, Rachel Marwood, Grace P. Lai, Stefan Hobi, Angel Almendros, Antonio Giuliano, Paweł M. Bęczkowski   +7 more
wiley   +1 more source

Southwest Research Institute assistance to NASA in biomedical areas of the technology [PDF]

Significant applications of aerospace technology were achieved. These applications include: a miniaturized, noninvasive system to telemeter electrocardiographic signals of heart transplant patients during their recuperative period as graded situations ...
Culclasure, D. F., Eckhardt, L.
core   +1 more source