Results 111 to 120 of about 1,087,603 (247)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

A Parameter-masked Mock Data Challenge for Beyond-two-point Galaxy Clustering Statistics

The Astrophysical Journal
The past few years have seen the emergence of a wide array of novel techniques for analyzing high-precision data from upcoming galaxy surveys, which aim to extend the statistical analysis of galaxy clustering data beyond the linear regime and the ...
The Beyond-2pt Collaboration, Elisabeth Krause, Yosuke Kobayashi, Andrés N. Salcedo, Mikhail M. Ivanov, Tom Abel, Kazuyuki Akitsu, Raul E. Angulo, Giovanni Cabass, Sofia Contarini, Carolina Cuesta-Lazaro, ChangHoon Hahn, Nico Hamaus, Donghui Jeong, Chirag Modi, Nhat-Minh Nguyen, Takahiro Nishimichi, Enrique Paillas, Marcos Pellejero Ibañez, Oliver H. E. Philcox, Alice Pisani, Fabian Schmidt, Satoshi Tanaka, Giovanni Verza, Sihan Yuan, Matteo Zennaro   +25 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Fitting complex ecological point process models with integrated nested Laplace approximation

, 2013
Summary 1. We highlight an emerging statistical method, integrated nested Laplace approximation (INLA), which is ideally suited for fitting complex models to many of the rich spatial data sets that ecologists wish to analyse. 2.
Gallego-Fernández, Juan B., Travis, Justin M. J., Illian, Janine Baerbel, Esquivias, M. Paz, Martino, Sara, Zunzunegui, Maria, Illian, Janine B., Warton, David, Sørbye, Sigrunn H., Travis, Justin M.   +9 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Optimisation issues in 3D multiple-point statistics simulation

, 2008
, 2008Multiple-point statistics simulation has gained wide acceptance in recent years and is routinely used for simulating geological heterogeneity in hydrocarbon reservoirs and aquifers.
Froidevaux, Roland, Renard, Philippe, Walgenwitz, Alexandre, Besson, Olivier, Straubhaar, Julien   +4 more
core  

Functional summary statistics and testing for independence in multi-type point processes on the surface of three dimensional convex shapes

The fundamental functional summary statistics used for studying spatial point patterns are developed for marked homogeneous and inhomogeneous point processes on the surface of a sphere.
Ward, Scott, Adams, Niall, Cohen, Edward
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

On the relationship between bilevel decomposition algorithms and direct interior-point methods [PDF]

, 2004
Engineers have been using bilevel decomposition algorithms to solve certain nonconvex large-scale optimization problems arising in engineering design projects.
Miguel, Angel Víctor de, Francisco J. Nogales, Angel Víctor De Miguel, Nogales Martín, Francisco Javier   +3 more
core  

Introducing the RadBioStat Educational Software: Computer-Assisted Teaching of the Random Nature of Cell Killing

Journal of Biomedical Physics and Engineering, 2014
The interaction of radiation with cells and tissues has a random nature. Therefore, understanding the random nature of cell killing that is determined by Poisson distribution statistics is an essential point in education of radiation biology ...
Safari A, Mortazavi SMJ, Mozdarani H
doaj