Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Spread Spectrum Modulation with Grassmannian Constellations for Mobile Multiple Access Underwater Acoustic Channels. [PDF]
Sensors (Basel), 2022 Bernard C, Bouvet PJ, Tomasi B.
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Joint Intra/Inter-Slot Code Design for Unsourced Multiple Access in 6G Internet of Things. [PDF]
Sensors (Basel), 2022 Li Y, Niu K, Dong C, Suo S, Lin J.
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Group-Connected Impedance Network of RIS-Assisted Rate-Splitting Multiple Access in MU-MIMO Wireless Communication Systems. [PDF]
Sensors (Basel), 2023 Kim MA +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Airborne-Platform-Assisted Transmission and Control Separation for Multiple Access in Integrated Satellite-Terrestrial Networks. [PDF]
Sensors (Basel)Huang C, Ma X, Xin X, Han W, Dong Y.
europepmc +1 more source
Throughput fairness trade-offs for downlink non-orthogonal multiple access systems in 5G networks. [PDF]
Heliyon, 2022 Abuajwa O +4 more
europepmc +1 more source