Results 161 to 170 of about 783,852 (382)

Multiattribute preference models with reference points [PDF]

open access: yes
In the context of multiple attribute decision making, preference models making use of reference points in an ordinal way have recently been introduced in the literature.
Denis Bouyssou, Thierry Marchant
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Pemilihan Guru Berprestasi Menggunakan DSS (Decision Support System) dengan Metode FMADM (Fuzzy Multiple Attribute Decission Making) dan SAW (Simple Additive Weighting) [PDF]

open access: yes, 2018
Sistem pendukung keputusan (decision support systems) merupakan bagian dari sistem informasi berbasis komputer termasuk sistem berbasis pengetahuan/manajemen pengetahuan yang dipakai untuk mendukung pengambilan keputusan dalam suatu organisasi atau ...
Jauhari, Z. (Zuraidah)   +1 more
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Open source environment to define constraints in route planning for GIS-T [PDF]

open access: yes, 2004
Route planning for transportation systems is strongly related to shortest path algorithms, an optimization problem extensively studied in the literature.
Pérez Vidal, Lluís   +1 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

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