Results 61 to 70 of about 2,303,768 (271)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Assessment of need for capacity building in framing multiple choice questions for undergraduate medical students

Journal of the Scientific Society, 2016
Background: Assessment is a critical component of medical education because tests have a powerful influence on student learning. Multiple choice question (MCQ) tests have been established as a part of undergraduate and postgraduate medical education.
Sunil Kumar Raina, Mitasha Singh, Abhilash Sood, Vishav Chander   +3 more
doaj   +1 more source

Item statistics derived from three-option versions of multiple-choice questions are usually as robust as four- or five-option versions: implications for exam design. [PDF]

, 2018
Different versions of multiple-choice exams were administered to an undergraduate class in human physiology as part of normal testing in the classroom. The goal was to evaluate whether the number of options (possible answers) per question influenced the ...
Loudon, Catherine, Macias-Muñoz, Aide
core  

Using item response theory to explore the psychometric properties of extended matching questions examination in undergraduate medical education [PDF]

, 2005
BACKGROUND: As assessment has been shown to direct learning, it is critical that the examinations developed to test clinical competence in medical undergraduates are valid and reliable. The use of extended matching questions (EMQ) has been advocated to
A Van Alphen, B Chopin, BA Fenderson, BD Wright, C Hagquist, CD Kreiter, D Andrich, D Andrich, D Andrich, DL Streiner, G Karabastos, G Rasch, G Rasch, GE Miller, GE Stone, General Medical Council, J Dobby, J Kehoe, J Umar, JC Impara, JM Bland, M Banerji, M Kane, R Hambleton, RD Luce, RF Burton, RK Hambelton, RM Smith, S Alagumalai, SM Case, SM Case, TA Van Batenburg, V Wass, W Wang, WH Angoff, WJ Popham   +35 more
core   +4 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

‘Creating assessments as an active learning strategy: what are students’ perceptions? A mixed methods study’ – a supplementary letter

Medical Education Online, 2019
This is a supplementary letter in response to Kurtz and colleagues’ recent publication exploring the creation of assessments for active learning, with the aim of discussing some of the important points raised by the authors and improvements based on our ...
Zhen Cahilog, Harry Yeuk Hei Lei, Safa Al-Musawi   +2 more
doaj   +1 more source

Evaluation of knowledge with multiple-choice tests: three of four options? Experience with admission examinations to medical and surgical postgraduate studies at University of Antioquia (Medellín, Colombia)

Iatreia, 2015
Introduction: The aim of this study was to evaluate the effect of reducing the number of response options per question on the psychometric indicators of an exam for admission to postgraduate medical studies, at University of Antioquia, in Medellín ...
Salazar Blanco, Olga Francisca, Vélez, Claudia Marcela, Zuleta Tobón, John Jairo   +2 more
doaj   +1 more source

Using Multiple Choice Questions to Assist Learning for Information Retrieval [PDF]

, 2011
A key issue in teaching and learning in information retrieval – particularly for library and information science students – is the gap in prior knowledge compared with the need for mathematics to conduct and evaluate searches. In this chapter, we examine
MacFarlane, A.
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source