Results 61 to 70 of about 2,308,146 (271)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

‘Creating assessments as an active learning strategy: what are students’ perceptions? A mixed methods study’ – a supplementary letter

Medical Education Online, 2019
This is a supplementary letter in response to Kurtz and colleagues’ recent publication exploring the creation of assessments for active learning, with the aim of discussing some of the important points raised by the authors and improvements based on our ...
Zhen Cahilog, Harry Yeuk Hei Lei, Safa Al-Musawi   +2 more
doaj   +1 more source

The use of computers as substitute tutors for marketing students [PDF]

, 1995
The use of computers as substitute tutors is associated primarily, though not exclusively, with multiple‐choice question formats (Ellington, Percival and Race, 1993). We report the findings of a project that involved the design, testing and evaluation of
Catterall, Miriam, Ibbotson, Patrick
core   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Item statistics derived from three-option versions of multiple-choice questions are usually as robust as four- or five-option versions: implications for exam design. [PDF]

, 2018
Different versions of multiple-choice exams were administered to an undergraduate class in human physiology as part of normal testing in the classroom. The goal was to evaluate whether the number of options (possible answers) per question influenced the ...
Loudon, Catherine, Macias-Muñoz, Aide
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Using multiple-choice questions, short questions and exercises to assess student performance

Acta Academica, 2006
Multiple-choice questions, short questions and exercises were used to assess the performance of students in environmental and water sciences at the University of the Western Cape (Bellville, South Africa).
Nebo Jovanovic, Abduraghiem Latief
doaj   +3 more sources

Guessing in Multiple Choice Questions: Challenges and Strategies [PDF]

مجله ایرانی آموزش در علوم پزشکی, 2014
Introduction: Guessing is one of the most challenging issues in multiple choice questions. Several strategies, such as negative scoring, have been suggested for preventing students from choosing the right answer just by chance.
Sara Mortaz Hejri, Mahboobeh Khabaz Mafinezhad, Mohammad Jalili   +2 more
doaj  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source