Results 111 to 120 of about 3,439,145 (349)

The MOSDEF survey: a stellar mass-SFR-metallicity relation exists at $z\sim2.3$

open access: yes, 2018
We investigate the nature of the relation among stellar mass, star-formation rate, and gas-phase metallicity (the M$_*$-SFR-Z relation) at high redshifts using a sample of 260 star-forming galaxies at $z\sim2.3$ from the MOSDEF survey.
Azadi, Mojegan   +17 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Residual mechanical properties of Ti-6Al-4V after simulated Space Shuttle reentry [PDF]

open access: yes
Oxidation and embrittlement are concerns in use of titanium foils for shielding advanced space transportation system vehicles during Earth reentry. Ti-6Al-4V in 0.003 in. and 0.035 in.
Clark, R. K., Unnam, J.
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Multiple rank tests for pairwise comparisons

open access: yes, 2012
Consider a balanced one way layout without a normality assumption. That is, assume each population has an unknown translation parameter and has a continuous distribution. We wish to test the Ck2 pairwise differences in translation parameters assuming there are k populations.We propose a multiple testing method based on ranks that is analogous to the ...
Cohen, Arthur, Sackrowitz, Harold
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Determining the number of breaks in a piecewise linear regression model [PDF]

open access: yes
In this paper we propose a sequential method for determining the number of breaks in piecewise linear structural break models. An advantage of the method is that it is based on standard statistical inference. Tests available for testing linearity against
Strikholm, Birgit
core  

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