Results 131 to 140 of about 3,439,145 (349)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A review of the validation of the Brief Cognitive Assessment for Multiple Sclerosis in Latin America
Multiple Sclerosis Journal - Experimental, Translational and ClinicalBackground The present review aimed to identify published studies that reported the validation of the Brief Cognitive Assessment for Multiple Sclerosis (BICAMS) in Latin America (LATAM).
Miriam E Jiménez-Maldonado* +11 more
doaj +1 more source
Simultaneous Test Procedures--Some Theory of Multiple Comparisons
The Annals of Mathematical Statistics, 1969 1. Introduction and summary. When a hypothesis is tested by a significanice test and is not rejected, it is generally agreed that all hypotheses implied by that hypothesis (its "components") must also be considered as non-rejected. However, when the hypothesis is rejected the question remains as to which components may also be rejected. Various writers
openaire +3 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Post-Hoc Tests in One-Way ANOVA: The Case for Normal Distribution
MethodologyWhen one-way ANOVA is statistically significant, a multiple comparison problem arises, hence post-hoc tests are needed to elucidate between which groups significant differences are found.
Joel Juarros-Basterretxea +5 more
doaj +1 more source
AnalyticsGenerally, following an omnibus (overall equality) test, multiple pairwise comparison (MPC) tests are typically conducted as the second step in a sequential testing procedure to identify which specific pairs (e.g., proportions) exhibit significant ...
Dewi Rahardja
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Discover EducationPartnership boosts problem solving skills in mathematics. This study aimed at examining the effect of integrating cooperative problem-solving with multiple representations, cooperative problem-solving and multiple representations instructional approaches
Gutema T. Wakjira +2 more
doaj +1 more source