Results 141 to 150 of about 50,764 (304)
On The Interaction Of Channeling/Segmentation Cracks Of Coating: Study On The Critical Spacing
, 2008 Channeling/segmentation cracks may arise in the coating subjected to in-plane tensile stress. The interaction between these multiple cracks, say the effect of the spacing between two adjacent cracks oil the behaviors of channels themselves and the ...
Wu, CW (reprint author), Chinese Acad Sci, Inst Mech, Ctr Mat Proc, 15 Beisihuanxi Rd, Beijing 100080, Peoples R China. +4 more
core +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Quantitative Identification of Multiple Cracks in a Rotor Utilizing Wavelet Finite Element Method
, 2012 Different from single crack identification method, the number of cracks should be firstly identified, and then the location and depth of each crack can be predicted for multiple cracks identification technology.
Bing Li, Hongbo Dong
core +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
ANALYTICAL SOLUTION OF STRESS INTENSITY FACTOR FOR MULTIPLE ELLIPTICAL HOLE EDGE CRACKS
Jixie qiangduThe aging aircraft fuselage skin contains multiple hole edge cracks,and the skin holes will change from circular holes to elliptical holes under loads.The calculation of stress intensity factors for multiple elliptical hole edge cracks is an important ...
doaj
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Multiple Cracks Detection in Pipeline Using Damage Index Matrix Based on Piezoceramic Transducer-Enabled Stress Wave Propagation. [PDF]
Sensors (Basel), 2017 Du G, Kong Q, Zhou H, Gu H.
europepmc +1 more source