Results 81 to 90 of about 16,396 (200)

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

A one-pot, one-step CRISPR-AapCas12b-based platform for sensitive and specific detection of Klebsiella pneumoniae

Sensing and Bio-Sensing Research
Klebsiella pneumoniae (K. pneumoniae) was a prevalent nosocomial pathogen and a major cause of neonatal sepsis, highlighting the critical need for simple, rapid, sensitive and reliable diagnosis for K. pneumoniae infection. While CRISPR-based diagnostics
Juan Zhou, Zirong Wu, Lei Yu, Xiaolan Huang, Fei Xiao, Yu Zhang, Linglong Wan, Jin Fu, Nan Jia, Min Chen, Chunrong Sun, Zhaomin Feng, Yi Wang   +12 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Population genetics of trypanosoma brucei rhodesiense: clonality and diversity within and between foci [PDF]

, 2013
African trypanosomes are unusual among pathogenic protozoa in that they can undergo their complete morphological life cycle in the tsetse fly vector with mating as a non-obligatory part of this development.
C. Michael R. Turner, Cooper, Anneli, Duffy, Craig W, Duffy, C.W., C Michael R Turner, Annette MacLeod, Cooper Anneli, MacLeod Annette, Lorna MacLean (126077), Lindsay Sweeney, MacLeod, A., MacLeod, Annette, Craig W. Duffy, Morrison, Liam; id_orcid, Tait, Andy, Morrison, L.J., Craig W Duffy, Sternberg, Jeremy, Sweeney, Lindsay, Morrison Liam J., Cooper, A., Sternberg, J., Tait, A., Duffy, Craig W., Jeremy Sternberg, Andy Tait, Lindsay Sweeney (51760), MacLean Lorna, Tait Andy, Duffy, Craig, Liam J Morrison, Tait, Andrew, Liam J. Morrison, Andy Tait (12786), Turner, C.M.R., Sweeney Lindsay, Liam J. Morrison (211421), Duffy Craig W., C. Michael R. Turner (12785), Turner, C M, MacLean, L., Craig W. Duffy (429693), Anneli Cooper (51759), Anneli Cooper, Turner, C Michael R, Morrison, Liam J, Jeremy Sternberg (485210), Sweeney, L., Annette MacLeod (12779), Sternberg Jeremy, Lorna MacLean, Turner C. Michael R., MacLean, Lorna, Morrison, Liam J., Turner, C. Michael R.   +54 more
core   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Image_2_Establishment and Application of a Multiple Cross Displacement Amplification Coupled With Nanoparticle-Based Lateral Flow Biosensor Assay for Detection of Mycoplasma pneumoniae.TIF

, 2019
Mycoplasma pneumoniae (M. pneumoniae) is responsible for pneumonia, and is a causative agent of other respiratory tract infections (e.g., bronchiolitis and tracheobronchitis). Herein, we established and applied a multiple cross displacement amplification
Shuting Quan (7418096), Jieqiong Li (327149), Xingyun Wang (3504179), Yacui Wang (7418093), Yonghong Wang (61187), Weiwei Jiao (503411), Adong Shen (356414), Xue Qi (3593900), Yi Wang (32470), Lin Sun (105539)   +9 more
core   +1 more source

Additional file 1 of Highly sensitive and rapid determination of Mycobacterium leprae based on real-time multiple cross displacement amplification

, 2023
Additional file ...
Shijun Li (165293), Xiaoyu Wei (2794636), Yi Tong (45623), Junfei Huang (9764927), Yijiang Chen (102749), Xinggui Yang (11216037), Jinlan Li (7510904), Xu Chen (432759)   +7 more
core   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie, Xiaotong Li, Venkata Sita Priyanka Illapani, Leigh N. Sepeta, Jason Schroeder, Chima O. Oluigbo, Madison M. Berl, William D. Gaillard, Nathan T. Cohen   +8 more
wiley   +1 more source

Image_1_Establishment and Application of a Multiple Cross Displacement Amplification Coupled With Nanoparticle-Based Lateral Flow Biosensor Assay for Detection of Mycoplasma pneumoniae.TIF

, 2019
Mycoplasma pneumoniae (M. pneumoniae) is responsible for pneumonia, and is a causative agent of other respiratory tract infections (e.g., bronchiolitis and tracheobronchitis). Herein, we established and applied a multiple cross displacement amplification
Shuting Quan (7418096), Jieqiong Li (327149), Xingyun Wang (3504179), Yacui Wang (7418093), Yonghong Wang (61187), Weiwei Jiao (503411), Adong Shen (356414), Xue Qi (3593900), Yi Wang (32470), Lin Sun (105539)   +9 more
core   +1 more source

Additional file 1 of Reliable detection of Burkholderia pseudomallei using multiple cross displacement amplification label-based biosensor

, 2022
Additional file 1: Table S1.
Xiaoxia Wang (14667), Xiong Zhu (535481), Licheng Wang (8293329), Chongzhen Wang (239055), Huaxiong Zhu (12227683)   +4 more
core   +1 more source