Results 161 to 170 of about 578,414 (184)

Topoisomerase I in multiple drug resistance

Cytotechnology, 1993
Topoisomerase I is a nuclear enzyme able to catalyse the relaxation of supercoiled DNA by introducing single-stranded breaks in DNA molecule. Its function seems important to prepare DNA for many processes such as recombination, DNA repair and RNA transcription.
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Multiple or pleiotropic drug resistance in yeast

Biochimica et Biophysica Acta (BBA) - General Subjects, 1991
The purpose of this review is to gather genetic and biochemical data established on multiple drug resistance in yeast, with a view to the implications that these findings may have for unravelling the mechanism of multidrug resistance in higher ...
Elisabetta Balzi, André Goffeau
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Molecular cytogenetics of multiple drug resistance

Cytotechnology, 1993
The refractory nature of many human cancers to multi-agent chemotherapy is termed multidrug resistance (MDR). In the past several decades, a major focus of clinical and basic research has been to characterize the genetic and biochemical mechanisms mediating this phenomenon.
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Drug resistance in multiple myeloma.

Seminars in hematology, 1997
The development of multidrug resistance (MDR) is a major obstacle to improving treatment outcomes in multiple myeloma. Recent studies have indicated that several specific mechanisms of MDR may be involved in clinically refractory multiple myeloma patients, such as expression of P-glycoprotein (P-gp), expression of the lung-resistance protein (LRP) and ...
Sonneveld, Pieter, Lokhorst, HM, Vossebelt, PJM   +2 more
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In vitro models of multiple drug resistance

1994
The emergence of drug resistance in many ways reflects evolution; those cells capable of surviving exposure to an environmental stress propagate. This is particularly important in cancer, where it has been estimated that 90% of the 500,000 annual cancer fatalities in the United States are influenced by drug resistance [1].
Susan Band Horwitz, Dalia Cohen, Lee M. Greenberger   +2 more
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Transmissible Drug-resistance Factors and Formation of Multiple Resistance

Nature, 1962
IN earlier reports several types of drug (chloramphenicol, Cm; tetracycline, Tc; streptomycin, Sm; sulphanilamide, Da) resistant Escherichia coli and Shigella were described1–3. It was also found that seven types of drug resistance are transmitted by cell-to-cell contact4.
S. Mitsuhashi, Kenji Harada
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Multiple Drug Resistance Mechanisms in Cancer

Molecular Biotechnology, 2010
Multiple drug resistance (multidrug resistance; MDR), a phenomenon whereby human tumours that acquire resistance to one type of therapy are found to be resistant to several other drugs that are often quite different in both structure and mode of action, has been recognised clinically for several decades. An important advance in our understanding of MDR
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Drug resistance in multiple myeloma.

Pathologie-biologie, 1999
Multidrug resistance (MDR) is a pleiotropic resistance against several unrelated drugs. It may be induced by prolonged exposure of cells to drugs such as doxorubicin, etoposide and vinca alkaloids. Once MDR develops in clinical tumors, it is a major obstacle for the improvement of treatment of multiple myeloma (MM).
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Multiple drug resistance in the pathogenic protozoa

Acta Tropica, 1994
Evidence for the phenomenon of multiple drug resistance (MDR) in the well studied pathogenic protozoa has been examined. This has been placed in the more familiar context of the MDR efflux transporters and the cloned mdr genes of mammalian cells. Homologues of the mdr gene family in protozoa and their possible role in drug efflux have been compared ...
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Management of Multiple Drug-Resistant Malaria

2004
Each year, malaria accounts for more deaths worldwide than any other parasitic disease, with mortality estimates of between 1.5 and 2.7 million (1). Malaria not only is associated with huge morbidity and mortality, but also it hampers economic growth, trapping endemic countries in a cycle of poverty and disease (2–4).The main disease burden is in ...
François Nosten, Elizabeth A. Ashley
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