Results 251 to 260 of about 792,799 (305)

MULTIPLE PATHWAY DRUG-RESISTANCE (REVIEW)

International Journal of Oncology, 1993
During the past few years it has become apparent that multiple mechanisms of resistance are playing a role in the clinical manifestations of drug resistance. In different organs and tumors, various components of the resistance phenotype are expressed to varying degrees.
J, Mattern, M, Volm
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Drug resistance in multiple myeloma

Cancer Treatment Reviews, 2018
Multiple myeloma (MM, plasma cell myeloma) is a malignant hematologic disease characterized by the clonal proliferation of malignant plasma cells. The treatment of MM has changed dramatically in recent years, with the introduction of new drugs into therapeutic strategies, both in the front line setting and in relapsed refractory disease.
Pawel, Robak, Izabela, Drozdz, Janusz, Szemraj, Tadeusz, Robak   +3 more
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Multiple drug resistance inAerobacter aerogenes

Antonie van Leeuwenhoek, 1967
Multiple drug resistance resulting from continued growth in various drugs in turn followed by serial subculture in the simultaneous presence of all the drugs has been studied. In this way strains ofA. aerogenes resistant, in considerable measure, to 3, 4 and 5 drugs have been obtained.
P G, Bolton, A C, Dean, P J, Rodgers
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Multiple-Drug-Resistant Tuberculosis

Clinical Infectious Diseases, 1994
The modern era of tuberculosis recently has been characterized by a rise in the number of cases of infection with multiple-drug-resistant (MDR) Mycobacterium tuberculosis. This acquisition of resistance to various established antituberculosis drugs has compromised both treatment and control programs worldwide.
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Multiple drug resistance and intermediate filaments

Cancer and Metastasis Review, 1996
One major obstacle to the successful treatment of epithelial derived tumors, such as breast and prostate carcinoma, is the presence of a multiple drug resistance phenotype. The drug resistance which is observed in growing epithelial derived cancer cells could either be an intrinsic, selected and/or an acquired characteristic.
A E, Cress, W S, Dalton
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Multiple drug resistance, antimutagenesis and anticarcinogenesis

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005
Many cells are protected from excess levels of exogenous chemicals, including mutagens and carcinogens as well as pharmaceutical agents, by being actively extruded through the action of one or more of a series of ATP-binding cassette drug transporter proteins. Those known to be important in humans are the multidrug resistance proteins (P-glycoproteins,
L. R. FERGUSON, DE FLORA, SILVIO
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Topoisomerase II in multiple drug resistance

Cytotechnology, 1993
Topoisomerase II is a target of alkaloid, anthracycline and related antitumor agents. Two types of multiple drug resistance are associated with these enzymes. In classical (typical) multidrug resistance, inhibitors are actively effluxed from cells by P-glycoprotein.
G A, Hofmann, M R, Mattern
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Drug resistance in multiple myeloma.

Seminars in hematology, 1997
The development of multidrug resistance (MDR) is a major obstacle to improving treatment outcomes in multiple myeloma. Recent studies have indicated that several specific mechanisms of MDR may be involved in clinically refractory multiple myeloma patients, such as expression of P-glycoprotein (P-gp), expression of the lung-resistance protein (LRP) and ...
Sonneveld, Pieter, Lokhorst, HM, Vossebelt, PJM   +2 more
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ChemInform Abstract: Multiple Drug Resistance

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lester A. Mitscher, Segaran P. Pillai, Elmer J. Gentry, Delbert M. Shankel   +3 more
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Topoisomerase I in multiple drug resistance

Cytotechnology, 1993
Topoisomerase I is a nuclear enzyme able to catalyse the relaxation of supercoiled DNA by introducing single-stranded breaks in DNA molecule. Its function seems important to prepare DNA for many processes such as recombination, DNA repair and RNA transcription.
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