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Multiple Drug Resistance Mechanisms in Cancer

Molecular Biotechnology, 2010
Multiple drug resistance (multidrug resistance; MDR), a phenomenon whereby human tumours that acquire resistance to one type of therapy are found to be resistant to several other drugs that are often quite different in both structure and mode of action, has been recognised clinically for several decades. An important advance in our understanding of MDR
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Molecular cytogenetics of multiple drug resistance

Cytotechnology, 1993
The refractory nature of many human cancers to multi-agent chemotherapy is termed multidrug resistance (MDR). In the past several decades, a major focus of clinical and basic research has been to characterize the genetic and biochemical mechanisms mediating this phenomenon.
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Drug resistance and drug development in multiple myeloma

Seminars in Oncology, 2002
Circumvention of drug resistance in multiple myeloma is a major obstacle to improving clinical outcomes for myeloma patients. Identification of several mechanisms of acquired drug resistance has led to the development of chemosensitizing agents that counter specific drug resistance mechanisms.
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Transmissible Drug-resistance Factors and Formation of Multiple Resistance

Nature, 1962
IN earlier reports several types of drug (chloramphenicol, Cm; tetracycline, Tc; streptomycin, Sm; sulphanilamide, Da) resistant Escherichia coli and Shigella were described1–3. It was also found that seven types of drug resistance are transmitted by cell-to-cell contact4.
S, MITSUHASHI, K, HARADA
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Drug resistance in multiple myeloma.

Pathologie-biologie, 1999
Multidrug resistance (MDR) is a pleiotropic resistance against several unrelated drugs. It may be induced by prolonged exposure of cells to drugs such as doxorubicin, etoposide and vinca alkaloids. Once MDR develops in clinical tumors, it is a major obstacle for the improvement of treatment of multiple myeloma (MM).
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies

Ca-A Cancer Journal for Clinicians, 2022
Paolo Tarantino   +2 more
exaly  

Multiple-Drug-Resistant Salmonella typhi

Clinical Infectious Diseases, 1993
A S, Mourad   +8 more
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Decreasing multiple drug-resistant organisms

Heart & Lung, 2011
Patricia W, Stone, Elaine, Larson
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MULTIPLE-DRUG-RESISTANT TUBERCULOSIS

The Pediatric Infectious Disease Journal, 1995
HEINZ F. EICHENWALD, R. F. Jacobs
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