Results 101 to 110 of about 948,028 (287)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Multiple elliptic gamma functions associated to cones

Advances in Mathematics, 2018
We define generalizations of the multiple elliptic gamma functions and the multiple sine functions, associated to good rational cones. We explain how good cones are related to collections of $SL_r(\mathbb{Z})$-elements and prove that the generalized multiple sine and multiple elliptic gamma functions enjoy infinite product representations and modular ...
openaire   +3 more sources

Multiplication Formulas for the Elliptic Gamma Function

, 2002
The elliptic gamma function is a generalization of the Euler gamma function. Its trigonometric and rational degenerations are the Jackson q-gamma function and the Euler gamma function. We prove multiplication formulas for the elliptic gamma function, whose degenerations are the Gauss-Askey multiplication formula for the Euler and trigonometric gamma ...
Felder, G., Varchenko, A.
openaire   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Certain classes of series associated with the Zeta function and multiple gamma functions

Journal of Computational and Applied Mathematics, 2000
The authors apply the theory of multiple Gamma functions, which was recently reviewed in the study of the determinants of Laplacians, in order to evaluate some families of series involving the Riemann zeta-function. By introducing a (presumably new) mathematical constant, they also systematically evaluate this constant and some definite integrals of ...
Choi, Junesang, Srivastava, H.M.
openaire   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Multisensory gamma stimulation mitigates the effects of demyelination induced by cuprizone in male mice

Nature Communications
Demyelination is a common pathological feature in a wide range of diseases, characterized by the loss of myelin sheath and myelin-supporting oligodendrocytes.
Daniela Rodrigues-Amorim, P. Lorenzo Bozzelli, TaeHyun Kim, Liwang Liu, Oliver Gibson, Cheng-Yi Yang, Mitchell H. Murdock, Fabiola Galiana-Melendez, Brooke Schatz, Alexis Davison, Md Rezaul Islam, Dong Shin Park, Ravikiran M. Raju, Fatema Abdurrob, Alissa J. Nelson, Jian Min Ren, Vicky Yang, Matthew P. Stokes, Li-Huei Tsai   +18 more
doaj   +1 more source

Quantifying network properties in multi-electrode recordings: Spatiotemporal characterization and inter-trial variation of evoked gamma oscillations in mouse somatosensory cortex in vitro

Frontiers in Computational Neuroscience, 2013
Linking the structural connectivity of brain circuits to their cooperative dynamics and emergent functions is a central aim of neuroscience research. Graph theory has recently been applied to study the structure-function relationship of networks, where ...
Cristian eCarmeli, Paolo eBonifazi, Paolo eBonifazi, Hugh eRobinson, Michael eSmall   +4 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source