Results 41 to 50 of about 293,301 (286)

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Imputation strategies when a continuous outcome is to be dichotomized for responder analysis: a simulation study

BMC Medical Research Methodology, 2019
Background In many clinical trials continuous outcomes are dichotomized to compare proportions of patients who respond. A common and recommended approach to handling missing data in responder analysis is to impute as non-responders, despite known biases.
Lysbeth Floden, Melanie L. Bell
doaj   +1 more source

A flexible network-based imputing-and-fusing approach towards the identification of cell types from single-cell RNA-seq data

BMC Bioinformatics, 2020
Background Single-cell RNA sequencing (scRNA-seq) provides an effective tool to investigate the transcriptomic characteristics at the single-cell resolution.
Yang Qi, Yang Guo, Huixin Jiao, Xuequn Shang   +3 more
doaj   +1 more source

Biplot visualisations of the differences between multiple imputation techniques for simulated categorical data

Discover Data
Proper handling of missing data is a necessity for all data driven research. Multiple imputation is considered as a superior approach to handle missing data.
Johané Nienkemper-Swanepoel
doaj   +1 more source

A comprehensive evaluation of factors affecting the accuracy of pig genotype imputation using a single or multi-breed reference population

Journal of Integrative Agriculture, 2022
Genotype imputation has become an indispensable part of genomic data analysis. In recent years, imputation based on a multi-breed reference population has received more attention, but the relevant studies are scarce in pigs.
Kai-li ZHANG, Xia PENG, Sai-xian ZHANG, Hui-wen ZHAN, Jia-hui LU, Sheng-song XIE, Shu-hong ZHAO, Xin-yun LI, Yun-long MA   +8 more
doaj   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Multiple imputation for estimation of an occurrence rate in cohorts with attrition and discrete follow-up time points: a simulation study

BMC Medical Research Methodology, 2010
Background In longitudinal cohort studies, subjects may be lost to follow-up at any time during the study. This leads to attrition and thus to a risk of inaccurate and biased estimations.
Soullier Noémie, de La Rochebrochard Elise, Bouyer Jean   +2 more
doaj   +1 more source

Evaluation of Odor Prediction Model Performance and Variable Importance according to Various Missing Imputation Methods

Applied Sciences, 2022
The aim of this study is to ascertain the most suitable model for predicting complex odors using odor substance data that has a small number of data and a large number of missing data.
Do-Hyun Lee, Saem-Ee Woo, Min-Woong Jung, Tae-Young Heo   +3 more
doaj   +1 more source

Multiple Imputation Using Gaussian Copulas [PDF]

, 2018
Missing observations are pervasive throughout empirical research, especially in the social sciences. Despite multiple approaches to dealing adequately with missing data, many scholars still fail to address this vital issue.
Bojinov, Iavor, Hollenbach, Florian M., Metternich, Nils W., Minhas, Shahryar, Minhas, Shahryar, Volfovsky, Alexander, Ward, Michael D.   +6 more
core   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source