Results 41 to 50 of about 175,566 (257)

A Comparative Evaluation of Imputation Techniques for Missing Data: A Simulation-Based Analysis

Computing&AI Connect
Missing data are a common occurrence in research and, if not appropriately addressed prior to analysis, may compromise the validity of study findings.
Rahibu Abdalla Abassi, Rocky Rajabu Akarro   +1 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Imputation strategies when a continuous outcome is to be dichotomized for responder analysis: a simulation study

BMC Medical Research Methodology, 2019
Background In many clinical trials continuous outcomes are dichotomized to compare proportions of patients who respond. A common and recommended approach to handling missing data in responder analysis is to impute as non-responders, despite known biases.
Lysbeth Floden, Melanie L. Bell
doaj   +1 more source

A flexible network-based imputing-and-fusing approach towards the identification of cell types from single-cell RNA-seq data

BMC Bioinformatics, 2020
Background Single-cell RNA sequencing (scRNA-seq) provides an effective tool to investigate the transcriptomic characteristics at the single-cell resolution.
Yang Qi, Yang Guo, Huixin Jiao, Xuequn Shang   +3 more
doaj   +1 more source

A comprehensive evaluation of factors affecting the accuracy of pig genotype imputation using a single or multi-breed reference population

Journal of Integrative Agriculture, 2022
Genotype imputation has become an indispensable part of genomic data analysis. In recent years, imputation based on a multi-breed reference population has received more attention, but the relevant studies are scarce in pigs.
Kai-li ZHANG, Xia PENG, Sai-xian ZHANG, Hui-wen ZHAN, Jia-hui LU, Sheng-song XIE, Shu-hong ZHAO, Xin-yun LI, Yun-long MA   +8 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source

Multiple imputation for estimation of an occurrence rate in cohorts with attrition and discrete follow-up time points: a simulation study

BMC Medical Research Methodology, 2010
Background In longitudinal cohort studies, subjects may be lost to follow-up at any time during the study. This leads to attrition and thus to a risk of inaccurate and biased estimations.
Soullier Noémie, de La Rochebrochard Elise, Bouyer Jean   +2 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Missing Value Imputation for RNA-Sequencing Data Using Statistical Models: A Comparative Study [PDF]

Journal of Statistical Theory and Applications (JSTA), 2016
RNA-seq technology has been widely used as an alternative approach to traditional microarrays in transcript analysis. Sometimes gene expression by sequencing, which generates RNA-seq data set, may have missing read counts.
Taban Baghfalaki, Mojtaba Ganjali, Damon Berridge   +2 more
doaj   +1 more source