Results 161 to 170 of about 12,363 (221)

Dual‐Drug‐Loaded Liposomes: Design Strategies, Mechanistic Insights, and Therapeutic Applications in Cancer

open access: yesMedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
Dual‐drug‐loaded liposomes enable the simultaneous delivery of hydrophilic and hydrophobic therapeutics to tumors, enhancing anticancer efficacy and overcoming multidrug resistance. Through rational formulation design and surface functionalization, these systems improve tumor targeting, modulate efflux mechanisms and EMT, and achieve synergistic ...
Neelam Sinha   +4 more
wiley   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

open access: yesMedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen   +3 more
wiley   +1 more source

Clinically significant prostate cancer detection with deep learning in a multi-center magnetic resonance imaging study. [PDF]

open access: yesSci Rep
Alzate-Grisales JA   +9 more
europepmc   +1 more source

Nitric Oxide in Cancer: Mechanisms, Dual Role, and Therapeutic Strategies

open access: yesMedComm – Oncology, Volume 5, Issue 3, September 2026.
Nitric oxide exerts concentration‐dependent dual roles in cancer, functioning as either a tumor promoter or suppressor. This review comprehensively examines NO's multifaceted regulation of tumor biology, including S‐nitrosylation signaling, metabolic reprogramming, immunemodulation, and therapy resistance, and highlights emerging therapeutic strategies
Jia Shao   +8 more
wiley   +1 more source

Four Directions, One Solution: Enabling Rapid Diffusion Tensor MRI for Ultra‐Low Field Using Deep Learning

open access: yesMagnetic Resonance in Medicine, Volume 96, Issue 3, Page 1413-1426, September 2026.
ABSTRACT Purpose This study revisits the tetrahedral encoding strategy originally proposed to accelerate Diffusion Tensor Magnetic Resonance Imaging (DT‐MRI) by reducing the requisite number of diffusion‐weighted measurements to four. We examine its practical limitations and explore how artificial intelligence (AI) can extend its utility. Specifically,
Joshua Mawuli Ametepe   +4 more
wiley   +1 more source

Artificial Intelligence in Veterinary Neurology: Comparative Insights From Human Medicine and Cross‐Species Technology Transfer

open access: yesVeterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Overview of major artificial intelligence applications in veterinary neurology, including neuroimaging, seizure prediction, gait and pain assessment, and prognostic modeling. The figure also highlights cross‐species technology transfer and key challenges, such as limited data, lack of standardization, and ethical concerns.
Kianoush Saberi   +12 more
wiley   +1 more source

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