Results 61 to 70 of about 2,203,514 (272)

On eigenvalues, case deletion and extremes in regression [PDF]

, 1990
This paper presents an approximation for assessing the effect of deleting an observation in the eigenvalues of the correlation matrix of a multiple linear regression modelo Applications in connection with the detection of collinearityinfluential ...
Velilla Cerdan, Santiago
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Application of Combined Multiple Linear Regression Model in Runoff Prediction

Renmin Zhujiang, 2021
In order to improve the hydrological prediction accuracy,a shuffled frog leaping algorithm (SFLA)-combined multiple linear regression (CMLR) runoff prediction model is proposed.This paper first builds a CMLR model based on principal component analysis ...
GUO Cunwen
doaj  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

A cross‐sectional study on predictors of patients' tinnitus severity

World Journal of Otorhinolaryngology-Head and Neck Surgery
Objective To identify factors that influence the severity of tinnitus via a hierarchical multiple linear regression model. Methods The study was a retrospective cross‐sectional analysis.
Teng‐Fei Li, Xu‐Dong Cha, Tian‐Yu Wang, Cai‐Quan Liang, Feng‐Zhen Li, Sheng‐Lei Wang, Hu Peng, Wen‐Wen Ren, Yue Deng, Huan‐Hai Liu   +9 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Análisis multivariable para la selección de las mejores zonas productivas de la formación Santo Tomás, sección 68, campo Gustavo Galindo Velasco

Revista Fuentes El Reventón Energético, 2019
In order to have an optimum development of hydrocarbon reservoirs, it is necessary to use a numerical simulation of reservoirs in which a large amount of geological and reservoir parameters are needed; therefore, an adequate record of information is ...
Fidel Vladimir Chuchuca Aguilar, Franciso Alberto Solórzano Cuesta, Kenny Fernando Escobar Segovia, Romel Ángel Erazo Bone, Yandry Xavier Murillo Zambrano   +4 more
doaj   +1 more source

Pengaruh Kualitas Layanan Agen Terhadap Kepuasan Nasabah PT. AXA Financial Indonesia Di Kota Palembang [PDF]

, 2016
This study was conducted to determine the effect of the agent service quality on customer satisfaction PT . AXA Financial Indonesia in Palembang. This type of research is done by using a surveys by distributing questionnaires to the respondents ...
Apelyani, Maria
core   +1 more source