Results 61 to 70 of about 2,215,776 (276)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Application of Combined Multiple Linear Regression Model in Runoff Prediction
Renmin Zhujiang, 2021 In order to improve the hydrological prediction accuracy,a shuffled frog leaping algorithm (SFLA)-combined multiple linear regression (CMLR) runoff prediction model is proposed.This paper first builds a CMLR model based on principal component analysis ...
GUO Cunwen
doaj
On eigenvalues, case deletion and extremes in regression [PDF]
, 1990 This paper presents an approximation for assessing the effect of deleting an observation in the eigenvalues of the correlation matrix of a multiple linear regression modelo Applications in connection with the detection of collinearityinfluential ...
Velilla Cerdan, Santiago
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
A cross‐sectional study on predictors of patients' tinnitus severity
World Journal of Otorhinolaryngology-Head and Neck SurgeryObjective To identify factors that influence the severity of tinnitus via a hierarchical multiple linear regression model. Methods The study was a retrospective cross‐sectional analysis.
Teng‐Fei Li +9 more
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Revista Fuentes El Reventón Energético, 2019 In order to have an optimum development of hydrocarbon reservoirs, it is necessary to use a numerical simulation of reservoirs in which a large amount of geological and reservoir parameters are needed; therefore, an adequate record of information is ...
Fidel Vladimir Chuchuca Aguilar +4 more
doaj +1 more source
Multiple linear regression based models for solar collectors [PDF]
, 2016 Mathematical modelling is the theoretically established tool to investigate and develop solar thermal collectors as environmentally friendly technological heat producers.
Kicsiny, Richárd
core