Results 61 to 70 of about 1,555,294 (317)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

A Data Imputation Model in Phasor Measurement Units Based on Bagged Averaging of Multiple Linear Regression

IEEE Access, 2018
Synchrophasor data from the phasor measurement unit (PMU) indicate the health of the electrical system. However, the PMU performance relies entirely on a supported communication network.
N. Le, W. Benjapolakul
semanticscholar   +1 more source

Pengaruh Dividend Per Share, Earning Per Share Dan Loan to Deposit Ratio Terhadap Harga Saham Pada Perusahaan Perbankan Di Bursa Efek Indonesia [PDF]

, 2013
This research aims to investiagte and analyse simultaneous and partial effects of dividend per share, earning per share and loan to deposit ratio on stock price at banking companies in Indonesia Stock Exchange. Sample of this research covers 12 out of 32
Persada, G. T. (Gandhi)
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Studying the Influence of Nitrogen Deposition, Precipitation, Temperature, and Sunshine in Remotely Sensed Gross Primary Production Response in Switzerland

Remote Sensing, 2019
Climate, soil type, and management practices have been reported as primary limiting factors of gross primary production (GPP). However, the extent to which these factors predict GPP response varies according to scales and land cover classes. Nitrogen (N)
Marta Gómez Giménez, Rogier de Jong, Armin Keller, Beat Rihm, Michael E. Schaepman   +4 more
doaj   +1 more source

The psychometric impacts of Karasek's demands and control scale on employees' job dissatisfaction [PDF]

, 2011
The aim of this study was to provide the reliability and validity of job factors and to analyze its association with Demands-Control Model and job dissatisfaction in two time cross-sectional study of Distribution Companies of Water and Power Development ...
Alharthey, Bandar, Rasli, Amran, Saif-ur-Rehman, Saif-ur-Rehman   +2 more
core  

Regional assessment of groundwater recharge in the lower Mekong Basin [PDF]

, 2017
Groundwater recharge remains almost totally unknown across the Mekong River Basin, hindering the evaluation of groundwater potential for irrigation. A regional regression model was developed to map groundwater recharge across the Lower Mekong Basin where
Douangsavanh, Somphasith, Lacombe, Guillaume, Pavelic, Paul, Vongphachanh, Sinxay   +3 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source