Results 71 to 80 of about 1,555,294 (317)

Pedotransfer function application for estimation of soil hydrophysical properties using parametric methods

Plant, Soil and Environment, 2007
Soil hydraulic properties are needed as input data to describe and simulate the transport of water and solutes in the soil profile. The most important characteristics are the soil moisture retention curve (SMRC) θ(h) and the hydraulic conductivity ...
S. Matula, K. Špongrová
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Building a Multiple Linear Regression Model With LEGO Brick Data

Journal of Statistics and Data Science Education, 2021
We present an innovative activity that uses data about LEGO sets to help students self-discover multiple linear regressions. Students are guided to predict the price of a LEGO set posted on Amazon.com (Amazon price) using LEGO characteristics such as the
Anna D. Peterson, Laura Ziegler
doaj   +1 more source

Residual log-periodogram inference for long-run relationships [PDF]

, 2006
We assume that some consistent estimator of an equilibrium relation between non-stationary series integrated of order d(0.5,1.5) is used to compute residuals (or differences thereof).
Hassler, U., Marmol, Francesc, Velasco, Carlos   +2 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Testing linear hypotheses in high-dimensional regressions

, 2012
For a multivariate linear model, Wilk's likelihood ratio test (LRT) constitutes one of the cornerstone tools. However, the computation of its quantiles under the null or the alternative requires complex analytic approximations and more importantly, these
Anderson T. W., Bai Z. D., Bai Z. D., Bai Z. D., Bai Z. D., Bartlett M. S., Box G. E.P., Dandan Jiang, Dempster A. P., Jian-feng Yao, Ledoit O., Mathai A. M., Schott J. R., Shurong Zheng, Srivastava M. S., Wilks S. S., Wilks S. S., Zheng S., Zhidong Bai   +18 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

The Effect of Company Size, Solvency and Audit Committee on Delay Audit [PDF]

, 2019
Delay in financial reporting, a company complaint. Because the investor no longer believes. Therefore, audit delay needs to be addressed. This study aims to analyze and describe audit delay factors. The research method used is quantitative with secondary
Saragih, M. R. (Muhammad)
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

TOXICITY MODELLING OF SOME ACTIVE COMPOUNDS AGAINST K562 CANCER CELL LINE USING GENETIC ALGORITHM-MULTIPLE LINEAR REGRESSIONS

Journal of the Turkish Chemical Society, Section A: Chemistry, 2016
This research entails the modelling of the toxicity of anticancer compounds on K562 cell line, where 112 compounds that make up the data set were divided into training and test set to be used for developing and validating the model respectively.
David Ebuka Arthur
doaj   +1 more source