Results 221 to 230 of about 351,954 (346)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

RPL29 as a radiotherapy-sensitive prognostic biomarker in multiple myeloma. [PDF]

World J Surg Oncol
Wang Y, Jia Q, Liu H, Li Z, Ma Y.
europepmc   +1 more source

Unraveling the Anti-Multiple Myeloma Activity of Alisol B 23-Acetate and Its Impact on the P38MAPK Pathway Through Integrated Analysis [PDF]

Hui Zhang, Peng Zhao, Jie Geng, Yuman Zhu, Xue-Chun Lu   +4 more
openalex   +1 more source

Protectin D1 and maresin 1 attenuate airway hyperreactivity induced by IL‐13 in human isolated small bronchi

British Journal of Pharmacology, EarlyView.
Background and Purpose Interleukin (IL)‐13 is implicated in airway hyperreactivity (AHR), a key feature of asthma. We explored the potential anti‐AHR activity of selected specialised pro‐resolving mediators (SPMs) in IL‐13‐induced AHR models, using human bronchial smooth muscle cells (BSMCs) and human isolated bronchi.
Willem Abma, Sven‐Erik Dahlén, Craig E. Wheelock, Mikael Adner, Mamdoh Al‐Amerie, Erik Sachs, Kasra Vali Jalali, Leonardo De Maria, Henric Olsson, Jesper Säfholm   +9 more
wiley   +1 more source

Characterization of cytogenetic abnormalities in Lebanese multiple myeloma patients. [PDF]

BMC Cancer
Najem G, Kharsa C, Kourie HR, Kattan J, Nasr F, El Karak F, Wakim J, Ghosn M, Chahine G, Hanna C, El Ferkh R, Farra C, Chebly A.   +12 more
europepmc   +1 more source

Body mass index throughout adulthood, physical activity, and risk of multiple myeloma: A prospective analysis in three large cohorts [PDF]

, 2018
Birmann, Brenda M, Buring, Julie E, Colditz, Graham A, Giovannucci, Edward, Lee, I-Min, Marinac, Catherine R, Rebbeck, Timothy R, Rosner, Bernard A, Townsend, Mary K   +8 more
core   +1 more source

Prognostic value of fatty acid metabolism-related signature and integrated analysis of the immune microenvironment in multiple myeloma [PDF]

Yang Yu, Feifei Che
openalex   +1 more source

NF‐κB Is a Potential Therapeutic Target for Histone Deacetylase Inhibitor‐Resistant Cutaneous T‐Cell Lymphoma

Cancer Science, EarlyView.
We identified a novel mechanism of resistance to histone deacetylase inhibitors (HDACi) in cutaneous T‐cell lymphoma (CTCL), mediated by NF‐κB activation. This finding highlights NF‐κB as a potential therapeutic target for overcoming HDACi resistance in CTCL.
Yuto Takahashi, Akihiro Kitadate, Sayaka Iwama, Wataru Kuroki, Ko Abe, Masahiro Yamada, Sho Ikeda, Hiroyuki Tagawa, Hideki Wakui, Masaki Hikida, Naoto Takahashi   +10 more
wiley   +1 more source

T Cells Dysfunction in Multiple Myeloma. [PDF]

Immunotargets Ther
Cai L, Zuo L, Wang G, Li Q, Ma C, Wu J, Sun C, Hu Y.   +7 more
europepmc   +1 more source

Targeting Overexpressed IDO in Stromal Cells as a Potential Therapeutic Strategy in Multiple Myeloma

Cancer Science, EarlyView.
IDO expression in stromal cells was upregulated by MM cells via the JAK–STAT1–NF‐κB–IRF1 signaling pathway. JAK inhibitor abolished IDO and IRF1 upregulation. ABSTRACT Stromal cells are an essential component of the tumor microenvironment (TME) in multiple myeloma (MM). Indoleamine 2,3‐dioxygenase 1 (IDO), an enzyme that metabolizes tryptophan (Trp) to
Toru Ebina, Masaki Ri, Yoshiaki Marumo, Tomoyuki Nakamura, Hirokazu Sasaki, Yoshiko Oshima, Takahiro Nakashima, Shinya Hagiwara, Arisa Asano, Shiori Kinoshita, Tomotaka Suzuki, Tomoko Narita, Ayako Masaki, Takaomi Sanda, Kazufumi Yamagata, Kohmei Kubo, Hirokazu Komatsu, Hirotake Sakuraba, Shinsuke Iida   +18 more
wiley   +1 more source