Results 121 to 130 of about 322,913 (349)

Effect of intravenous clarithromycin in patients with sepsis, respiratory and multiple organ dysfunction syndrome: a randomized clinical trial [PDF]

, 2022
Eleni Karakike, Brendon P. Scicluna, Maria Roumpoutsou, Ioannis Mitrou, Niki Karampela, Athanasios Karageorgos, Konstantinos Psaroulis, Eleni Massa, Achillefs Pitsoulis, Panagiotis Chaloulis, Evanthia Pappa, Irene T. Schrijver, Frantzeska Frantzeskaki, Malvina Lada, Nicolás Dauby, David De Bels, Ioannis V. Floros, Souzana Anisoglou, Eleni Antoniadou, Maria Patrani, Glykeria Vlachogianni, Eleni Mouloudi, Anastasia Antoniadou, David Grimaldi, Thierry Roger, W. Joost Wiersinga, Iraklis Tsangaris, Evangelos J. Giamarellos‐Bourboulis   +27 more
openalex   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Fatal pediatric case of Kounis syndrome and sepsis: a case report

International Journal of Emergency Medicine
Background Kounis syndrome is a hypersensitivity reaction that induces acute coronary artery events, nevertheless its pediatric occurrence remains rare and often underdiagnosed.
Tamara Berezna, Olha Synoverska, Nadiya Fomenko, Iryna Pylyuk, Khrystyna Lazurkevych, Viktoria Bedei, Taras Kotyk   +6 more
doaj   +1 more source

Sepsis-Associated Coagulopathy: Diagnosis With Hematologic Biomarkers and Role in the Development of Multiple Organ Dysfunction Syndrome and Mortality [PDF]

, 2013
Jean‐François Mathieu, Sylvie Boucher, Rocky DiFruscia, Jean-Pierre Pellerin   +3 more
openalex   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Predictors of Multiple Organ Dysfunction Syndrome in Patients with Major Trauma

Siriraj Medical Journal, 2017
Objective: To study the predictive power of systemic inflammatory response syndrome (SIRS) scores, platelet count, and blood glucose level for multiple organ dysfunction syndrome (MODS) in patients with major trauma.
Uraiporn Siritep, Orapan Thosingha, Prangtip Chayaput   +2 more
doaj  

Fecal microbiota transplantation for multiple organ dysfunction syndrome [PDF]

, 2016
Nathan J. Klingensmith, Craig M. Coopersmith   +1 more
openalex   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Determining predictors of underlying etiology and clinical deterioration in patients with physiologic instability in the emergency department [PDF]

, 2013
Thesis (M.A.)--Boston UniversityShock is a critical state defined by inadequate oxygen delivery to tissues. It is well known in the critical care community that early diagnosis and treatment of shock are crucial to improving patient outcomes. However, in
Day, Danielle E.
core   +1 more source

Ivabradine: a preliminary observation for a new terapeutic role in patients with multiple organ dysfunction syndrome [PDF]

, 2014
Vincenzo De Santis, Giacomo Frati, Ernesto Greco, Luigi Tritapepe   +3 more
openalex   +1 more source