Results 111 to 120 of about 6,285,374 (227)

Signaling systems affecting the severity of multiple osteochondromas

Bone, 2018
Multiple osteochondromas (MO) syndrome is a dominant autosomal bone disorder characterized by the formation of cartilage-capped bony outgrowths that develop at the juxtaposition of the growth plate of endochondral bones. MO has been linked to mutations in either EXT1 or EXT2, two glycosyltransferases required for the synthesis of heparan sulfate (HS ...
Virginia Piombo, Katja Jochmann, Daniel Hoffmann, Manuela Wuelling, Andrea Vortkamp   +4 more
openaire   +3 more sources

The Pathophysiological Functions of Heparanases: From Evolution, Structural and Tissue‐Specific Perspectives

The FASEB Journal, Volume 39, Issue 17, 15 September 2025.
Heparanase 1 (HPSE1) and Heparanase 2 (HPSE2) exhibit opposing expression patterns and functions in pathological contexts, such as cancer. Here, we describe their specific expression in immune cells and their implications in skin diseases. Although they are structurally similar and considered to be ‘cousins’, we found no common ancestor and that HPSE2 ...
Elham Vahdatahar, Clément Daviaud, Hugo Main, Rachel Havret, Claire Debarnot, Laure Favot‐Laforge, Jean‐François Jégou, Ingrid Fruitier‐Arnaudin, Antoine Dufour, Romain Vivès, Franck Morel, Yves Bourne, Kévin Baranger   +12 more
wiley   +1 more source

Multiple Intraarticular Osteochondromas of the Knee

Orthopedics and Rheumatology Open Access Journal, 2022
Osteochondroma is the most common benign growing bone tumor that usually affects the knee joint area. It often involves the long bone metaphysis, which occurs extraarticularly. Despite this, single intraarticular osteochondroma is rarely reported in the literature, but multiple knee osteochondromas is very rare and has not been reported so far.
openaire   +1 more source

Update on pediatric hip imaging [PDF]

, 2017
Hip disorders are common in children. Prompt diagnosis and treatment are important because of the potential complications. Symptoms are frequently nonspecific, and clinical examination can be difficult and unreliable, especially in smaller children ...
Herregods, Nele, Jans, Lennart, Jaremko, Jacob, Vanhoenacker, Filip   +3 more
core   +2 more sources

A Case of Multiple Osteochondroma in the Rat.

Journal of Veterinary Medical Science, 1995
The occurrence of spontaneous osteochondroma in rats is extremely rare and only a few cases have been reported. Spontaneous multiple osteochondroma was found in a male SD strain rat, at the age of 58 weeks from the control group in a toxicity study. Histological findings of both a walnut-sized mass involving the humerus and scapula of right forelimb ...
H, Iwata, S, Yamamoto, S, Mikami, S, Yamakawa, Y, Hirouchi, K, Kobayashi, M, Enomoto   +6 more
openaire   +3 more sources

MiRNA profiling of whole trabecular bone: identification of osteoporosis-related changes in MiRNAs in human hip bones [PDF]

, 2015
Background MicroRNAs (miRNAs) are important regulators of gene expression, with documented roles in bone metabolism and osteoporosis, suggesting potential therapeutic targets.
Balcells, Susana, De-Ugarte, Laura, Díez Pérez, Adolfo, Garcia-Giralt, Natalia, Grinberg, Daniel, Güerri-Fernández, Robert, Martinez-Diaz, Santos, Mellibovsky, Leonardo, Nogués, Xavier, Universitat Autònoma de Barcelona, Urreizti, Roser, Yoskovitz, Guy   +11 more
core   +2 more sources

Multiple Hereditary Osteochondromas [PDF]

Mayo Clinic Proceedings, 2019
Lori A, Erickson, Carrie Y, Inwards
openaire   +2 more sources

Thoracic Cord Compression by an Osteochondroma in a Patient with Multiple Osteochondromas.

Orthopedics & Traumatology, 1992
Osteochondromas rarely compress the spinal cord or cauda equina. A case of thoracic cord compression by an osteochondroma combined with multiple osteochondromas is reported. A 21-year-old man was admitted to our hospital with a 3-month history of spastic gait and sensory disturbance.
Hidehiro Yanagi, Katumi Suzuki, Toshitaka Nakamura, Shinichi Mishima, Akihiko Hijioka   +4 more
openaire   +2 more sources

Spine Osteochondromas: are they always rare and harmless? A case series of six symptomatic cases

Coluna/Columna
Osteochondroma is the most common benign bone tumor, though spinal involvement is rare. This study presents a case series of six symptomatic spinal osteochondromas, including both solitary forms and cases associated with multiple hereditary exostoses ...
GABRIEL FARIAS ALVES, ALDERICO GIRãO CAMPOS DE BARROS, LUíS E. CARELLI   +2 more
doaj   +1 more source

Spinal cord compression by an osteochondroma in a patient with multiple osteochondromas.

Orthopedics & Traumatology, 1989
A case of spinal cord compression by an osteochondroma with multiple osteochondromas was reported.A 10-year-old boy was admitted to our hospital with 6-month history of spastic gait in the right leg.Neurological examination demonstrated mild weakness of the right lower extremity. There were relative hyper-reflexes in the right leg. Plain roentgenograms
Hideaki Kubota, Akira Okue, Tomoki Ishizaki, Nobuyuki Matsuguchi, Takayasu Shindou, Keishi Tahara, Yukio Esaki   +6 more
openaire   +2 more sources