Results 211 to 220 of about 7,318,203 (396)

Disruption of Gut Microbiota‐Mediated De Novo NAD+ Synthesis Contributes to the Development of Polycystic Ovary Syndrome

open access: yesAdvanced Science, EarlyView.
This study demonstrates that patients with PCOS exhibit altered gut microbial profiles, and FMT from PCOS patients induces PCOS‐like symptoms in mice. Specifically, gut dysbiosis reduces 3‐HAA levels in the context of PCOS. Administration of 3‐HAA to mice alleviates PCOS by promoting de novo NAD+ synthesis.
Ke Chen   +6 more
wiley   +1 more source

Spatial Transcriptomics Reveals Transcriptomic and Immune Microenvironment Reprogramming during Thyroid Carcinoma Dedifferentiation

open access: yesAdvanced Science, EarlyView.
Spatial transcriptomic analysis of Anaplastic thyroid carcinoma (ATC)‐differentiated thyroid carcinoma (DTC) coexisting tumors reveals that coexisting DTC regions with ATC‐like genomic alterations undergo sequential transcriptomic reprogramming and immune microenvironment remodeling, ultimately evolving into a full ATC pathological phenotype.
Kang Ning   +19 more
wiley   +1 more source

RIPK1 Drives JAK1‐STAT3 Signaling to Promote CXCL1‐Mediated Neutrophil Recruitment in Sepsis‐Induced Lung Injury

open access: yesAdvanced Science, EarlyView.
This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun   +15 more
wiley   +1 more source

Nociceptive Nerve‐Derived CGRP Exacerbates Uterine Fibrogenesis in Adenomyosis by Promoting CD140b+ CD146+ Fibroblast Differentiation

open access: yesAdvanced Science, EarlyView.
This study investigates adenomyosis fibrosis in relation to nociceptive nerves. Nociceptive nerve‐secreted CGRP promotes RAMP1hi CD140b+ CD146+ fibroblast differentiation into myofibroblasts through ERK activation, causing severe fibrosis. Rimegepant‐induced CGRP/RAMP1 signaling blockade alleviates fibrosis and restores fertility in a mouse model. This
Zi Ye   +11 more
wiley   +1 more source

High multiple pregnancy rates after double embryo transfers in human: a retrospective cohort study. [PDF]

open access: yesReprod Fertil
Dietrich JE   +4 more
europepmc   +1 more source

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