Results 281 to 290 of about 951,521 (353)

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Mediating effects of maternal blood lipids and glucose on the relationship between pre-pregnancy body mass index and newborn birth weight in women with gestational diabetes mellitus. [PDF]

BMC Pregnancy Childbirth
Li H, Xiang Z, Li H, Xie C, Li Z, Liang Y, Gao L, Li Z.   +7 more
europepmc   +1 more source

Evaluating the Association between Exposure to Multiple Metals and Adverse Pregnancy Outcomes Based on a Multi−Step Statistical Analysis Strategy

Changyuan Yu, Dongyang Zhang, Zelian Li, Muxin Zhai, Yuanyuan Yang, Shiwei Ren, Weilong Lin, Yunxia Cao, Dongmei Ji, Chunmei Liang   +9 more
openalex   +1 more source

Prenatal ultrasound diagnosis of fetal cardiac rhabdomyoma and analysis of clinical outcomes. [PDF]

Quant Imaging Med Surg
Zhao J, Jia P, Zhang Q, Li T, Ma B, Yan Z.   +5 more
europepmc   +1 more source

Effect of assisted hatching on pregnancy outcomes following 1,678,872 single embryo transfers based on the Japan Assisted Reproductive Technology Registry. [PDF]

Sci Rep
Kusamoto A, Harada M, Kawahara T, Koike H, Kunitomi C, Fukui Y, Sanada Y, Takahashi N, Matsuo M, Makabe T, Urata Y, Izumi G, Ooi N, Hiraike O, Osuga Y, Hirota Y.   +15 more
europepmc   +1 more source

Establishment and validation of a prediction model for small vulnerable newborns: a retrospective study. [PDF]

J Glob Health
Xiao C, Xu C, Zhang L, Lai D.
europepmc   +1 more source

The role of allostatic load in adverse pregnancy outcomes: a multisystem, developmental perspective. [PDF]

Front Glob Womens Health
Costello LA, Banker SM, Morales S, Barber M, Hockett C, McCormack L, Rauth VA, Elliott AJ, Shuffrey LC.   +8 more
europepmc   +1 more source

Effects of different ovulation induction protocols on pregnancy outcomes of fresh cycles in patients undergoing in vitro fertilization-embryo transfer with donor sperm. [PDF]

Arch Gynecol Obstet
Su L, Jing X, Zeng L, Luo L, Wang H, Li R, Chi H.   +6 more
europepmc   +1 more source