Results 51 to 60 of about 951,521 (353)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The early second-trimester multifetal pregnancy reduction improves pregnancy outcome

Clinical and Experimental Obstetrics & Gynecology, 2021
Purpose: To evaluate pregnancy outcome of selective second-trimester multifetal pregnancy reduction (MFPR) compared with that of first-trimester MFPR, and control group which consists of women with ongoing primary twin pregnancies. Materials and Methods:
Jing-Jing Jiang, Ting Han, Yan-Hui Zhu
doaj   +1 more source

Prevalence and risk of Down syndrome in monozygotic and dizygotic multiple pregnancies in Europe: implications for prenatal screening. [PDF]

, 2014
OBJECTIVE: To determine risk of Down syndrome (DS) in multiple relative to singleton pregnancies, and compare prenatal diagnosis rates and pregnancy outcome.
Addor, M.C., Boyle, B., Dolk, H., Garne, E., Gatt, M., Haeusler, M., Latos-Bielenska, A., Lelong, N., Loane, M., McConkey, R., McDonnell, R., Morris, J.K., Mullaney, C., O'Mahony, M.   +13 more
core   +3 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Impact of sitagliptin on endometrial mesenchymal stem-like progenitor cells : a randomised, double-blind placebo-controlled feasibility trial [PDF]

, 2020
Background: Recurrent pregnancy loss (RPL) is associated with the loss of endometrial mesenchymal stem-like progenitor cells (eMSC). DPP4 inhibitors may increase homing and engraftment of bone marrow-derived cells to sites of tissue injury.
Brighton, Paul (Paul J.), Brosens, Jan J., Da Costa, Maria José Minhoto Diniz, Ewington, Lauren J., Fishwick, Katherine, Fujihara, Risa, Kimani, Peter K., Lacey, Lauren, Lucas, Emma S., Muter, Joanne, Polanco, Angela, Quenby, Siobhan, Takeda, Satoru, Tewary, Shreeya   +13 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

MANAGEMENT OF PREGNANCY AND DELIVERY IN MULTIPLE PREGNANCY

Alʹmanah Kliničeskoj Mediciny, 2016
The problem of multiple pregnancy management is of scientific and pragmatic interest, because in the last years, there is an increase of numbers of multiple pregnancies, especially due to wider use of assisted reproductive technologies.
V. I. Krasnopol'skiy, S. V. Novikova, E. B. Tsivtsivadze, A. A. Zharova   +3 more
doaj   +1 more source

Sonographic cervical volumetry in higher order multiple gestation [PDF]

, 2001
Objective:The aim of this study of multifetal pregnancies was the comparison of three-dimensional (3D) volumetry of the cervix, conventional sonographic cervical length measurement and clinical assessment.
Fuchshuber, Susanne, Heer, Ivo, Hepp, Hermann, Hillemanns, Peter, Janssen, Udo, Strauss, Alexander   +5 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Moninkertainen ilo : Opas vanhemmille monikkoraskaudesta ja arjesta pienokaisten kanssa [PDF]

, 2012
Opinnäytetyön tarkoituksena oli tehdä opas monikkovanhemmille raskaus- ja lapsivuodeajasta. Vanhemmat saavat oppaan Kuopion yliopistollisen sairaalan (KYS) äitiyspoliklinikalta.
Sirviö, Johanna, Tuononen, Tiina
core