Results 121 to 130 of about 9,019,411 (282)

Coexistence of primary colorectal follicular lymphoma and multiple myeloma: a case report

, 2018
Makoto Saito,1 Kencho Miyashita,2 Yosuke Miura,3 Reiki Ogasawara,1 Minoru Kanaya,1 Koh Izumiyama,1 Akio Mori,1 Takeshi Kondo,1 Masanori Tanaka,1 Masanobu Morioka,1 Shinya Tanaka4 1Department of Internal Medicine and Hematology, Aiiku Hospital, Sapporo ...
Morioka M, Miura Y, Kondo T, Tanaka S, Kanaya M, Izumiyama K, Saito M, Ogasawara R, Mori A, Miyashita K, Tanaka M   +10 more
core  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Intracranial ependymoma in an adult patient with multiple primary malignancies. [PDF]

BMJ Case Rep, 2023
Thong SY, Chua B, Winter C, Jiwrajka M.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Corrigendum: Risk and prediction of multiple primary malignancies after early gastric cancer. [PDF]

Front Oncol, 2023
Chen N, Shi L, Ge J, Jia R, Jiang J.
europepmc   +1 more source

Multiple Primary Malignancies Involving Papillary Thyroid Carcinoma: A Three‐Case Series

Clinical Case Reports
Papillary thyroid carcinoma (PTC) may be associated with second primary malignancies. We report three cases with melanoma, diffuse large B‐cell lymphoma, and breast carcinoma occurring synchronously or metachronously.
Katayoon Ghasemi, Amirhossein Rezaei Latifi, Mohammad Salari   +2 more
doaj   +1 more source

Exploring the Trends of Multiple Primary Malignancies - An Institutional Study from a Tertiary Care Cancer Centre in North Kerala

Background Multiple primary malignancies (MPM) are the subsequent malignancies occurring in an individual with an already diagnosed malignancy. This study was conducted to determine the proportion, clinicopathological characteristics, treatment intent ...
Praveen Kumar Shenoy, Saranya Purushothaman, Ratheesan K, Sangeetha Keloth Nayanar   +3 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source